Target resequencing of the candidate region of the susceptibility gene for autism by using the next-generation sequencer
Project/Area Number |
22791107
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
|
Research Institution | The University of Tokyo |
Principal Investigator |
TOCHIGI Mamoru 東京大学, 医学部附属病院, 講師 (40456116)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 自閉症 / 候補遺伝子 / 次世代シークエンサー / コピー数多型(CNV) / 遺伝子 / ゲノム / 脳神経疾患 |
Research Abstract |
As a result of the exome sequencing of a four-generation-extending autism spectrum disorder(ASD) family, several candidate genes, which completely co-segregate with the disease, were found and may lead to a new finding. In the copy number variation(CNV) analysis of 163 trios of ASD, eight de novo CNVs(> 500kb) were found in seven trios, one of which was duplication in 15q11. 2.
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Report
(3 results)
Research Products
(9 results)