| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
It is postulated that oxidative stress may be involved in the pathophysiology of some psychiatric disorders, however, sophisticated method to investigate redox status in brain is lacking even in animal studies. In this study, we aimed to confirm the alteration in redox status induced by repeated cocaine administration in situ in the rat striatum. First, we found that an anti-oxidative stress compound, N-acetylcysteine, reduced many synaptic proteins in the nucleus accumbens as the consequence of repeated cocaine administration. Second, it appeared that the production of glutathione, the major endogenous antioxidant, shifted from astroglias to neurons. These results suggest a necessity of more cell-type-specific approach to detect the alteration of glutathione metabolism.
|
