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A multifaceted study of brain network in schizophrenia: morphological, physiological and functional approach

Research Project

Project/Area Number 22791116
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionUniversity of Fukui

Principal Investigator

TAKAHASHI Tetsuya  福井大学, 医学部附属病院, 講師 (00377459)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords統合失調症 / 脳内ネットワーク / 認知制御 / functional MRI / 脳波 / 非線形解析 / ガンマオシレーション / 非線形解析(マルチスケールエントロピー、サンプルエントロピー)
Research Abstract

Reliability of fMRI activations with the Stroop task was preliminary investigated in order to assess a potential ability of fMRI is to monitoring the pathogenic progress or therapeutic interventions. The Stroop task can elicit brain activations in anterior cingulate and dorsolateral prefrontal that have a relatively high degree of reproducibility. As for EEG study, changes of cortical function with amphetamine were investigated in schizophrenia and healthy controls using EEG complexity analysis. As a result, amphetamine tends to reduce cortical function in healthy control which was not seen in schizophrenia.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Effects of electroconvulsive therapy on neural complexity in patients with depression: Report of three cases

    • Author(s)
      Okazaki R, Takahashi T, Ueno K, Takahashi K, Higashima M, Wada Y
    • Journal Title

      J Affect Disord

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complexity of spontaneous brain activity in mental disorders.

    • Author(s)
      Takahashi T
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Effect of amphetamine on complexity behavior of cortical oscillations in schizophrenia.2011

    • Author(s)
      Takahashi T, Walker C, Verviest R, Ueno K, Wada Y, Takahashi K, Cho R
    • Organizer
      Society of Biological Psychiatry, 66th Annual Meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Reliability of fMRI BOLD activations in the cognitive control network during Stroop task2010

    • Author(s)
      Takahashi T, Cho RY, Ramaswamy R, Carter C, Cohen J
    • Organizer
      Society of Biological Psychiatry, 65th Annual Meeting
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2010-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Reliability of fMRI BOLD activations in the cognitive control network during Stroop task2010

    • Author(s)
      T.Takahashi, et al.
    • Organizer
      Society of Biological Psychiatry 65th Annual Meeting
    • Place of Presentation
      New Orleans (U.S.A.)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reproducibility of fMRI BOLD signal in the cognitive control network in the Stroop paradigm2010

    • Author(s)
      RY.Cho, T.Takahashi, et al.
    • Organizer
      The 17th Annual Cognitive Neuroscience Society Meeting
    • Place of Presentation
      Montreal (Canada)
    • Year and Date
      2010-04-19
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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