Effect of treatment for depression on oxidative stress marker and brain-derived neurotrophic factor

• Project/Area Number: 22791117
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: University of Yamanashi
• Principal Investigator: TAMAOKI Toshio 山梨大学, 医学部・附属病院, 助教 (60345709)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: うつ病 / 認知症 / 酸化ストレス / 脳由来神経栄養因子 / コリンエステラーゼ / 栄養状態 / 気分障害 / 痴呆 / 脳・神経 / 神経新生

Research Abstract

It is pointed out that the depression is related to dementia closely. It may prevent dementia if depression is treated appropriately. Oxidative stress markers and brain-derived neurotrophic factor are related to dementia and depression. I measured an oxidative stress marker and brain-derived neurotrophic factor before and after treatment for depression. As a result, I found that serum brain-derived neurotrophic factor related to the index of nutritional status including serum choline esterase. From this, it was supposed that serum brain-derived neurotrophic factor changed parallel to nutritional status.

Research Products

• [Presentation] 初老期・老年期うつ病患者において血清中のBDNFとコリンエステラーゼは正相関する (2012)
  • Author(s): 玉置寿男,田中宏一,布村明彦,小林慶太,安田あやの,大槻正孝,山口雅靖,藤井友和,北原裕一,安田和幸,小林薫,松下裕,石黒浩毅,本橋伸高
  • Organizer: 第27回日本老年精神医学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2012-06-21