| Project/Area Number |
22791118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKAHASHI Taro 浜松医科大学, 子どものこころの発達研究センター, 特任研究員 (30402358)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Katsuaki 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00285040)
MATSUZAKI Hideo 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00334970)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 精神薬理学 / 非定型抗精神病薬 / 統合失調症 / 神経幹細胞 / 仮死モデル / クロザピン / 早期介入 |
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| Research Abstract |
The asphyxia model of schizophrenia, in which rat pups were exposed to 15 min of intrauterine anoxia during Cesarean section birth, showed a reduction in hippocampal dentate granule cells at 6 weeks of age and dopaminergic dysregulation at 12 weeks after birth, both have been regarded as schizophrenia-like phenotypes. Using this model, we examined in this study whether administration of antipsychotics to mothers prevent the development of schizophrenia-like features in their offspring. Pregnant female rats were administered daily either with clozapine(0. 5 or 5. 0 mg/kg), haloperidol(0. 1 or 1. 0 mg/kg), or saline by intraperitoneal infusions. Their pups were delivered Cesarean section with or without asphyxia. Twelve weeks after birth, pups were challenged with methamphetamine(0. 5 or 2. 0 mg/kg) or saline, and their locomotor activity were measured. As a result, there were no significant effects of either dose of clozapine or haloperidol on methamphetamine-induced locomotor activity in those pups.
These results failed to support the hypothesis that maternal administrations of antipsychotic might have a prophylactic effect on the development of psychotic features in their offspring.
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