Genome-wide association study of schizophrenia in a Japanese population and follow-up study

• Project/Area Number: 22791120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: ALEKSIC Branko 名古屋大学, 大学院・医学系研究科, 特任准教授 (60547511)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: JGWAS / MAGI2 / 統合失調症 / 認知機能 / 実行機能 / 認知機能障害 / 全ゲノム関連解析 / WCST / 関連研究

Research Abstract

A synapse scaffolding protein, MAGI2, interacts with a variety of functional molecules including glutamate receptors and is presumed to be relevant to cognitive impairment in schizophrenia. In this study, we conducted an association analysis of MAGI2 in schizophrenia and evaluated an effect of this gene on cognitive function. As a result, two polymorphisms(rs2190665、rs4729938) showed suggestive evidence of association with schizophrenia. In addition, rs2190665 was found to be related to impairment of executive function.

Research Products

• [Journal Article] Evaluation of factors affecting Continuous Performance Test Identical Pairs Version score of schizophrenic patients in a Japanese clinical sample Schizophrenia Research and Treatment (2012)
  • Author(s): Koide T, Aleksic B, Kikuchi T, Banno M, Kohmura K, Adachi Y, Kawano N, Iidaka t, Ozaki N.
  • Volume: (In press)
  • Peer Reviewed
• [Journal Article] Evaluation of factors affecting Continuous Performance Test Identical Pairs Version score of schizophrenic patients in a Japanese clinical sample (2012)
  • Author(s): 小出隆義
  • Journal Title: Schizophrenia Research and Treatment Volume: (未定)(印刷中)
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia in a Japanese population (2011)
  • Author(s): Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O' Donovan
  • Journal Title: Biol Psychiatry Volume: 69(5) Pages: 472-8
  • Peer Reviewed
• [Journal Article] A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population (2011)
  • Author(s): Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N
  • Journal Title: PLoS One Volume: 6(12)
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia in a Japanese population (2011)
  • Author(s): 池田匡志、アレクシッチ・ブランコ
  • Journal Title: Biol Psychiatry Volume: 69 Pages: 472-478
  • Peer Reviewed
• [Journal Article] A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population (2011)
  • Author(s): 阪野正大
  • Journal Title: PLoS One Volume: (印刷中)(in press)
  • Peer Reviewed
• [Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility (2010)
  • Author(s): Kushima I, et al.
  • Journal Title: Schizophr Bull
  • Peer Reviewed
• [Journal Article] Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. (2010)
  • Author(s): Aleksic B, et al.
  • Journal Title: Schizophr Res Volume: 118(1-3) Pages: 113-7
  • Peer Reviewed
• [Journal Article] Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. (2010)
  • Author(s): Kushima I, et al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 153B (3) Pages: 786-91
  • Peer Reviewed
• [Journal Article] Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population. (2010)
  • Author(s): Kushima I, et al.
  • Journal Title: J Hum Genet Volume: 55 (3) Pages: 133-6
  • Peer Reviewed
• [Journal Article] Genome-Wide Association Study of Schizophrenia in a Japanese Population (2010)
  • Author(s): Ikeda M, et al.
  • Journal Title: Biol Psychiatry
  • Peer Reviewed
• [Journal Article] Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data (2010)
  • Author(s): Yoshimi A, et al.
  • Journal Title: Schizophr Res Volume: 124 Pages: 216-222
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects (2010)
  • Author(s): Koide T, et al.
  • Journal Title: J Hum Genet Volume: 55 Pages: 469-72
  • Peer Reviewed
• [Journal Article] Copy number variation in schizophrenia in the Japanese population (2010)
  • Author(s): Ikeda M, et al.
  • Journal Title: Biol Psychiatry Volume: 67 Pages: 283-6
  • Peer Reviewed
• [Presentation] Association study and expression analysis between MAGI2 and schizophrenia (2011)
  • Author(s): 小出隆義
  • Organizer: WCPG 2011
  • Place of Presentation: ワシントン
  • Year and Date: 2011-09-10
• [Presentation] Association study and cognitive function analysis of MAGI2 as a candidate gene for schizophrenia (2011)
  • Author(s): 小出隆義
  • Organizer: WFSBP 2011
  • Place of Presentation: チェコプラハ
  • Year and Date: 2011-05-31
• [Presentation] Association study and expression analysis between MAGI2 and schizophrenia (2011)
  • Author(s): Koide T, Aleksic B, Yoshimi A, et al.
  • Organizer: Paper presented at : WCPG 2011, world congress of psychiatric genetics
  • Place of Presentation: Omni Shoreham Hotel, Washintong, DC, United States
• [Presentation] Association study and cognitive function analysis of MAGI2 as a candidate gene for schizophrenia (2011)
  • Author(s): Koide T, Aleksic B, Ikeda M, et al.
  • Organizer: Paper presented at : WFSBP 2011 : world congress of biological psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Association study and expression analysis between MAGI2 and schizophrenia (2011)
  • Author(s): Koide T, Aleksic B, Yoshimi A, et al.
  • Organizer: Paper presented at :名古屋大学グローバルCOEプログラム機能分子医学への神経疾患・腫瘍の融合拠点第3回国際シンポジウム
  • Place of Presentation: ミッドランドホール、ミッドランドスクエア、名古屋市、日本
• [Presentation] Overview of the single SNP analysis of Japanese genome wide association study of schizophrenia (2010)
  • Author(s): Aleksic Branko
  • Organizer: XVIII World Congress on Psychiatric Genetics
  • Place of Presentation: Athens、Greece
  • Year and Date: 2010-10-04
• [Remarks]
  • URL: http://kenpro.mynu.jp:8001/Profiles/0062/0006240/profile.html