A Genetic association study between schizophrenia risk gene, ZNF804A and endophenotypes in schizonrenia patients

• Project/Area Number: 22791123
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: YASUDA Yuka 大阪大学, 医学系・研究科, 特任研究員 (20448062)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 統合失調症 / 遺伝子解析 / ZNF804A / 中間表現型 / パーソナリティ

Research Abstract

A single nucleotide polymorphism(SNP), rs1344706, in the Zinc Finger Protein804A(ZNF804A) gene, has been implicated in susceptibility to schizophrenia. We investigated an association between the ZNF804A genotype of rs1344706 and schizotypal personality traits using the Schizotypal Personality Questionnaire(SPQ) in healthy subjects. The results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects.

Research Products

• [Journal Article] The p250GAP Gene Is Associated with Risk for Schizophrenia and Schizotypal Personality Traits (2012)
  • Author(s): Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M.
  • Journal Title: PLoS One Volume: 7(4)
  • Peer Reviewed
• [Journal Article] No associations found between the genes situated at 6p22. 1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia (2012)
  • Author(s): Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159B(4) Pages: 456-64
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia : Evidence from a gene-based case-control study and gene expression analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159B(4) Pages: 405-13
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as Candidate Gene for Schizophrenia : Evidences From Voxel-Based Morphometry and Mutation Screening (2012)
  • Author(s): Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N.
  • Journal Title: Schizophr Bull
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia : evidence from a case-control study and meta-analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M.
  • Journal Title: Psychiatry Res
  • Peer Reviewed
• [Journal Article] A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait (2012)
  • Author(s): Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
  • Journal Title: Neurosci Lett Volume: 513(2) Pages: 204-8
  • Peer Reviewed
• [Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
  • Journal Title: PLoS One Volume: 7(1)
  • Peer Reviewed
• [Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects (2012)
  • Author(s): Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
  • Journal Title: Neurosci Res Volume: 72(2) Pages: 187-93
  • Peer Reviewed
• [Journal Article] 大阪大学神経科精神科の児童思春期専門外来における臨床研究について (2012)
  • Author(s): 安田由華、橋本亮太、山森英長、大井一高、福本素由己、梅田-矢野知美、伊藤彰、武田雅俊
  • Journal Title: 月刊精神科 Volume: 20(3) Pages: 312-317
• [Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer' s disease in the mild cognitive impairment stage (2011)
  • Author(s): Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: 1(1) Pages: 20-30
  • Peer Reviewed
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia (2011)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
  • Journal Title: World J Biol Psychiatry Volume: (in press)
  • Peer Reviewed
• [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M
  • Journal Title: World J Biol Psychiatry
  • Peer Reviewed
• [Journal Article] Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia : a magnetoencephalography-beamformer study (2011)
  • Author(s): Ikezawa K, Ishii R, Iwase M, Kurimoto R, Canuet L, Takahashi H, Nakahachi T, Azechi M, Ohi K, Fukumoto M, Yasuda Y, Iike N, Takaya M, Yamamori H, Kazui H, Hashimoto R, Yoshimine T, Takeda M
  • Journal Title: Neurosci Res Volume: 71(3) Pages: 235-43
  • Peer Reviewed
• [Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene (2011)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M.
  • Journal Title: Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene Volume: 495 Pages: 216-220
  • Peer Reviewed
• [Journal Article] 統合失調症の中間表現型 (2011)
  • Author(s): 橋本亮太、安田由華、大井一高、福本素由己、梅田知美、岡田武也、山森英長、武田雅俊
  • Journal Title: 精神科治療学 Volume: 26(11) Pages: 1363-1369
• [Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene (2011)
  • Author(s): Yasuda Y, et al
  • Journal Title: Neuroscience Letters Volume: 495 Issue: 3 Pages: 216-220
  • DOI: 10.1016/j.neulet.2011.03.069
  • Peer Reviewed
• [Journal Article] 統合失調症の中間表現型 (2011)
  • Author(s): 橋本亮太、安田由華, 他
  • Journal Title: 精神科治療学 Volume: 26 Pages: 1363-1369
• [Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia (2010)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
  • Journal Title: Am J Med Genet B Neuropsychiatry Genet Volume: 153B(8) Pages: 1459-1464
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer' s disease, but does not show association with disease in a Japanese cohort (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30(4) Pages: 302-308
  • Peer Reviewed
• [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population (2010)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry Volume: 11(7) Pages: 852-857
  • Peer Reviewed
• [Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia. (2010)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. Volume: 153B(8) Pages: 1459-1464
  • Peer Reviewed
• [Journal Article] Association study of the KIBRA gene with memory performance in a Japanese population. (2010)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, TANAKA T, Kudo T, Kamino Kouzin, Ishii R, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry. Volume: 11(7) Pages: 852-857
  • Peer Reviewed
• [Journal Article] KIBRA Genetic Polymorphism Influences Episodic Memory in Alzheimer's Disease, but Does Not Show Association with Disease in a Japanese Cohort. (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30 Pages: 302-308
  • Peer Reviewed
• [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate phenotype study in schizophrenia- (2011)
  • Author(s): 橋本亮太、安田由華, 他
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-05-22
• [Presentation] 統合失調症の候補遺伝子の精神生物学 (2011)
  • Author(s): 橋本亮太、安田由華、大井一高、福本素由己、山森英長、梅田知美、岡田武也、高雄啓三、小林克典、楯林義孝、宮川剛、貝淵弘三、岩田仲生、尾崎紀夫、武田雅俊
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
• [Presentation] Dysbindin : Possible target molecule for antipsychotic development (2011)
  • Author(s): Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Takeda M
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 遺伝子の遺伝子多型とシゾイドパーソナリティ特性の関連-Association of the ZNF804A genotype with schizotypal personality trait- (2011)
  • Author(s): 安田由華、橋本亮太、大井一高、福本素己、梅田矢野知美、山森英長、大河内智、岩瀬真生、数井裕光、岩田仲生、武田雅俊
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate phenotype study in schizophrenia- (2011)
  • Author(s): 橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia (2010)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
  • Organizer: The 49th ACNP(American College of Neuropsychopharmacology) Annual Meeting
• [Book] 「精神遅滞」、看護学テキスト「疾病と治療III」 (2010)
  • Author(s): 安田由華、橋本亮太
  • Publisher: 南江堂
• [Book] 看護学テキスト(「疾病と治療III」) (2010)
  • Author(s): 安田由華、橋本亮太
  • Publisher: 南江堂
• [Remarks]
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm