A Genetic association study between schizophrenia risk gene, ZNF804A and endophenotypes in schizonrenia patients
Project/Area Number |
22791123
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | Osaka University |
Principal Investigator |
YASUDA Yuka 大阪大学, 医学系・研究科, 特任研究員 (20448062)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 統合失調症 / 遺伝子解析 / ZNF804A / 中間表現型 / パーソナリティ |
Research Abstract |
A single nucleotide polymorphism(SNP), rs1344706, in the Zinc Finger Protein804A(ZNF804A) gene, has been implicated in susceptibility to schizophrenia. We investigated an association between the ZNF804A genotype of rs1344706 and schizotypal personality traits using the Schizotypal Personality Questionnaire(SPQ) in healthy subjects. The results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] The p250GAP Gene Is Associated with Risk for Schizophrenia and Schizotypal Personality Traits2012
Author(s)
Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M.
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Journal Title
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Peer Reviewed
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[Journal Article] No associations found between the genes situated at 6p22. 1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia2012
Author(s)
Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Pages: 456-64
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Peer Reviewed
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[Journal Article] Functional genetic variation at the NRGN gene and schizophrenia : Evidence from a gene-based case-control study and gene expression analysis2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Pages: 405-13
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Peer Reviewed
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[Journal Article] Analysis of the VAV3 as Candidate Gene for Schizophrenia : Evidences From Voxel-Based Morphometry and Mutation Screening2012
Author(s)
Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N.
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[Journal Article] A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait2012
Author(s)
Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
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Journal Title
Neurosci Lett
Volume: 513(2)
Pages: 204-8
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Peer Reviewed
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[Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
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Peer Reviewed
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[Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects2012
Author(s)
Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
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Journal Title
Neurosci Res
Volume: 72(2)
Pages: 187-93
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Peer Reviewed
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[Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer' s disease in the mild cognitive impairment stage2011
Author(s)
Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
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Journal Title
Dement Geriatr Cogn Dis Extra
Volume: 1(1)
Pages: 20-30
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Peer Reviewed
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[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
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Journal Title
World J Biol Psychiatry
Volume: (in press)
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Peer Reviewed
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[Journal Article] Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia : a magnetoencephalography-beamformer study2011
Author(s)
Ikezawa K, Ishii R, Iwase M, Kurimoto R, Canuet L, Takahashi H, Nakahachi T, Azechi M, Ohi K, Fukumoto M, Yasuda Y, Iike N, Takaya M, Yamamori H, Kazui H, Hashimoto R, Yoshimine T, Takeda M
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Journal Title
Neurosci Res
Volume: 71(3)
Pages: 235-43
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Peer Reviewed
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[Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene2011
Author(s)
Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M.
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Journal Title
Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
Volume: 495
Pages: 216-220
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Peer Reviewed
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[Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia2010
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
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Journal Title
Am J Med Genet B Neuropsychiatry Genet
Volume: 153B(8)
Pages: 1459-1464
Related Report
Peer Reviewed
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[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer' s disease, but does not show association with disease in a Japanese cohort2010
Author(s)
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
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Journal Title
Dement Geriatr Cogn Disord
Volume: 30(4)
Pages: 302-308
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Peer Reviewed
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[Journal Article] Association study of KIBRA gene with memory performance in a Japanese population2010
Author(s)
Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
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Journal Title
World J Biol Psychiatry
Volume: 11(7)
Pages: 852-857
Related Report
Peer Reviewed
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[Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia.2010
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet.
Volume: 153B(8)
Pages: 1459-1464
Related Report
Peer Reviewed
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[Journal Article] Association study of the KIBRA gene with memory performance in a Japanese population.2010
Author(s)
Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, TANAKA T, Kudo T, Kamino Kouzin, Ishii R, Iwase M, Kazui H, Takeda M.
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Journal Title
World J Biol Psychiatry.
Volume: 11(7)
Pages: 852-857
Related Report
Peer Reviewed
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[Journal Article] KIBRA Genetic Polymorphism Influences Episodic Memory in Alzheimer's Disease, but Does Not Show Association with Disease in a Japanese Cohort.2010
Author(s)
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
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Journal Title
Dement Geriatr Cogn Disord
Volume: 30
Pages: 302-308
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Peer Reviewed
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[Presentation] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia2010
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
Organizer
The 49th ACNP(American College of Neuropsychopharmacology) Annual Meeting
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