| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The neurodevelopmental hypothesis is proposed as one of the hypotheses to explain critical cause of the mental disorder. This is the theory that fetal brain development abnormality may make an onset risk of mental disorder. In this study, we examined the effect of prenatal glucocorticoid hormone exposure on the cerebral cortex formation/neural network formation of rodent. This study has revealed so far that the glucocorticoid exposure disturbs the migration of interneuron which is to become GABAergic neuron and causes the heterogeneous distribution in the cortex. Furthermore, it has also revealed that prenatal glucocorticoid exposure reduces the volume of the prefrontal cortex and causes the anisotropy anomaly in the white matter in peri-adolescent period.
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