| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Four functional polymorphism of the pericentriolar material 1 (PCM1) gene is not associated with the schizophrenia in a Japanese population. The PCM1 protein expresses more in E17 than in adult. The PCM1 protein exists at centrosome until D.I.V. 7 days, diminishes until D.I.V. 14 days, and doesn’t exist on spine in D.I.V. 28 days. The period of expression and the distribution of PCM1 are same with r-tubulin. The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene has been reported to be associated with type 2 diabetes mellitus (T2DM). Four polymorphism of ARHGEF11 which was reported to be associated with T2DM were also associated with the paranoid subtype of schizophrenia in a Japanese population. ARHGEF11 has co-localized with PSD95, one of the post synaptic marker. ARHGEF11 may be one of the genetic links between schizophrenia and T2DM and have integrated the synaptic morphology through the interaction withDisrupted-In-Schizophrenia-1 (DISC-1).
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