The functionalanalysis of the Pericentriolar material 1 (PCM1), one of the candidate genes of schizophrenia at synapse
Project/Area Number |
22791125
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | Okayama University |
Principal Investigator |
TAKAKI Manabu 岡山大学, 岡山大学病院, 助教 (60452570)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 統合失調症 / 臨床精神分子遺伝学 / Pericentriolar material 1 (PCM1) / シナプス / Bardet-Biedl syndrome (BBS) / The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) / PSD-95 / PCM1 / ARHGEF11 / BBS4 / 2型糖尿病 / 認知機能 / 機能解析 / クロザピン |
Research Abstract |
Four functional polymorphism of the pericentriolar material 1 (PCM1) gene is not associated with the schizophrenia in a Japanese population. The PCM1 protein expresses more in E17 than in adult. The PCM1 protein exists at centrosome until D.I.V. 7 days, diminishes until D.I.V. 14 days, and doesn’t exist on spine in D.I.V. 28 days. The period of expression and the distribution of PCM1 are same with r-tubulin. The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene has been reported to be associated with type 2 diabetes mellitus (T2DM). Four polymorphism of ARHGEF11 which was reported to be associated with T2DM were also associated with the paranoid subtype of schizophrenia in a Japanese population. ARHGEF11 has co-localized with PSD95, one of the post synaptic marker. ARHGEF11 may be one of the genetic links between schizophrenia and T2DM and have integrated the synaptic morphology through the interaction withDisrupted-In-Schizophrenia-1 (DISC-1).
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia2011
Author(s)
Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H
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Journal Title
Curr Neuropharmacol
Volume: 9(1): 190-4
Issue: 1
Pages: 190-194
DOI
Related Report
Peer Reviewed
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[Journal Article] Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence2011
Author(s)
Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H
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Journal Title
Curr Neuropharmacol
Volume: 9(1):183-9
Issue: 1
Pages: 183-189
DOI
Related Report
Peer Reviewed
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[Journal Article] Association study of serine racemase gene with methamphetamine psychosis2011
Author(s)
Yokobayashi E, Ujike H, Kotaka T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S
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Journal Title
Curr Neuropharmacol
Volume: 9(1):169-75
Issue: 1
Pages: 169-175
DOI
Related Report
Peer Reviewed
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[Journal Article] Association Between 5HT1b Receptor Gene and Methamphetamine Dependence2011
Author(s)
Ujike H, Kishimoto M, Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, YamM, Iwata N, Iyo M, Sora I, Ozaki N
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Journal Title
Curr Neuropharmacol
Volume: 9(1):163-8
Issue: 1
Pages: 163-168
DOI
Related Report
Peer Reviewed
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[Journal Article] Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac-12010
Author(s)
Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A
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Journal Title
Nat Neurosci
Volume: 13(3):327-32
Issue: 3
Pages: 327-332
DOI
Related Report
Peer Reviewed
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