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An i nvest i gat i on i nto the cause of and i tory ha I I uc i nat i on and and i tory information processing deficits in schizophrenia

Research Project

Project/Area Number 22791129
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

HIRANO Yoji  九州大学, 医学研究院, 学術研究員 (90567497)

Research Collaborator KANBA Shigenobu  九州大学, 医学研究院, 教授 (50195187)
ONITSUKA TOSHIAKI  九州大学, 大学病院, 講師 (00398059)
KASAI Kiyoto  東京大学, 医学部付属病院, 教授 (80322056)
UENO Takefumi  九州大学, 医学研究院, 特任准教授 (00441668)
HIRANO Shogo  九州大学, 医学研究院, 共同研究員 (10568984)
ORIBE Naoya  九州大学, 医学研究院, 学術研究員
NAKAMURA Itta  九州大学, 医学研究院, 大学院生
SPENCER Kevin M.  HARVARD MEDICAL SCHOOL, Vamc, Associate Professor
MCCARLEY Robert W.  HARVARD MEDICAL SCHOOL, Vamc, Professor
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords統合失調症 / 幻聴 / Auditory information processing / Audio-Visual integration / 脳磁図 / 脳波 / 時間周波数解析 / 聴覚情報処理 / 聴覚-視覚情報統合 / 聴覚情報処理機構 / 誘発磁場
Research Abstract

The aim of this study was to investigate the neural basis of auditory hallucination in schizophrenia. We analyzed the neural activities related to auditory hallucinations or the audio-visual integration process using new neurophysiological methods. We found that abnormalγ-band neural oscillation activities evoked during audio, visual and audio-visual integration were prominently involved in the neural basis of auditory hallucinations in schizophrenia. These results may contribute to the development of diagnoses, therapies and provide clues to the underlying cause of schizophrenia.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (33 results)

All 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (15 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia2012

    • Author(s)
      Tsunoda T, Kanba S, Ueno T, Hirano Y, Hirano S, Maekawa T, Onitsuka T
    • Journal Title

      Clinical Neurophysiology

      Volume: in press

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia2012

    • Author(s)
      Tsunoda T, et al
    • Journal Title

      Clinical Neurophysiology

      Volume: (In press) Issue: 9 Pages: 1762-1768

    • DOI

      10.1016/j.clinph.2012.01.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia2011

    • Author(s)
      Tsuchimoto R, Kanba S, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Oda Y, Miura T, Onitsuka T
    • Journal Title

      Schizophrenia Research

      Volume: 133 Pages: 99-105

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal signatures of an abnormal auditory system in stuttering2011

    • Author(s)
      Kikuchi Y, Ogata K, Umesaki T, Yoshiura T, Kenjo M, Hirano Y, Okamoto T, Komune S, Tobimatsu S
    • Journal Title

      Neuroimage

      Volume: 55 Pages: 891-899

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stability of the Rayleigh distribution2011

    • Author(s)
      Ueno T, Hirano S, Hirano Y, Oribe N, Nakamura I, Oda Y, Kanba S, Onitsuka T
    • Journal Title

      Proc Inter Cong Imaging and Signal Processing IEEE

      Volume: 5 Pages: 2402-2403

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の顔認知障害と社会機能障害の関連2011

    • Author(s)
      鬼塚俊明, 大林長二, 角田智哉, 平野昭吾, 平野羊嗣, 前川敏彦, 上野雄文
    • Journal Title

      認知神経科学

      Volume: 13 Pages: 64-70

    • NAID

      130006895660

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stability of the Rayleigh distribution2011

    • Author(s)
      Ueno T, et al
    • Journal Title

      Proc Inter Cong Imaging Signal Processing IEEE

      Volume: 5 Pages: 2402-2403

    • DOI

      10.1109/cisp.2011.6100689

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal signatures of an abnormal auditory system in stuttering.2011

    • Author(s)
      Kikuchi Y, et al
    • Journal Title

      Neuroimage

      Volume: 55 Pages: 891-899

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : an MEG study2010

    • Author(s)
      Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Ueno T, Kasai K, Kanba S
    • Journal Title

      Bipolar Disorder

      Volume: 12 Pages: 804-812

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auditory gating deficit to human voices in schizophrenia : a MEG study2010

    • Author(s)
      Hirano Y, Hirano S, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T
    • Journal Title

      Schizophrenia Reseach

      Volume: 117 Pages: 61-67

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auditory gating deficit to human voices in schizophrenia : a MEG study.2010

    • Author(s)
      Hirano Y, et al
    • Journal Title

      Schizophrenia Research

      Volume: 117 Pages: 61-67

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : a MEG study2010

    • Author(s)
      Oribe N, et al
    • Journal Title

      Bipolar Disorder

      Volume: 12 Pages: 804-812

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Visual P300 deficits in individuals in prodromal state and first episode schizophrenia2012

    • Author(s)
      Oribe N, Niznikiewicz M, Hirano Y, E. C. del Re, Tasoff T, Spencer KM, McCarleyRW
    • Organizer
      Society of Biological Psychiatry 67th Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2012-05-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional and Structural Evidence2012

    • Author(s)
      Hirano Y, Quan M, Niznikiewicz M, McCarley RW, Spencer KM : Abnormalγ-band Auditory Steady-State Responses in Schizophrenia
    • Organizer
      Society of Biological Psychiatry 67th Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2012-05-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Aberrant Gamma-band Auditory Responses in Chronic Schizophrenia2012

    • Author(s)
      Hirano Y, Quan M, Niznikiewicz M, McCarley RW, Spencer KM
    • Organizer
      012 McGovern MEG Symposium
    • Place of Presentation
      Cambridge, USA
    • Year and Date
      2012-04-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible preattentive dysfunction in patients with bipolar disorder : MEG study2012

    • Author(s)
      Oribe N and Hirano Y
    • Organizer
      2012 McGovern MEG Symposium
    • Place of Presentation
      Cambridge, USA
    • Year and Date
      2012-04-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Abnormal Gamma-band Auditory Steady-State Responses in Chronic Schizophrenia2012

    • Author(s)
      Hirano Y, Quan M, Niznikiewicz M, McCarley RW, Spencer KM
    • Organizer
      2012 Mysell Research Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Visual P300 deficits in individuals in prodromal state and first episode schizophrenia2012

    • Author(s)
      Oribe N and Hirano Y, Tasoff T, Spencer KM, Niznikiewicz M, McCarley RW
    • Organizer
      2012 Mysell Research Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Electrophysiological and GABA and Glutamate MRS Measures in SPD : Preliminary Results2012

    • Author(s)
      E. C. del Re and Hirano Y, Lin A, Voglmaier M, Oribe N, Tasoff T, Spencer KM, Niznikiewicz M, McCarley RW
    • Organizer
      2012 Mysell Research Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Electrophysiologicar and GABA and Glutamate MRS Measures in SPD : Preliminary Results2012

    • Author(s)
      E.C.del Re, Hirano Y (co-first), et al
    • Organizer
      2012 Mysell Research Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Audio-visual multimodal integration activity in human brain : An MEG study2011

    • Author(s)
      Nakamura I and Hirano Y, Ohara N, Oribe N, Hirano S, Ueno T, Onitsuka T
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Face processing deficits and social dysfunction in schizophrenia : A magnetoencephalography study2011

    • Author(s)
      Ohara N, Kanba S, Ueno T, Hirano Y, Hirano S, Oribe N, Onituka T
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Audio-visual multimodal iategration activity in human brain : An MEG study2011

    • Author(s)
      Nakamura I, Hirano Y (co-first), et al
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症における高周波数帯域γ同期性の減少2011

    • Author(s)
      土本利架子,神庭重信,平野昭吾,織部直弥,上野雄文,平野羊嗣,中村一太,小田祐子, 三浦智史,鬼塚俊明
    • Organizer
      第11回精神疾患と認知機能研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Reduced high frequency gamma synchronization and auditory hallucination symptoms in schizophrenia2011

    • Author(s)
      Tsuchimoto R, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Oda Y, Onitsuka T, Kanba S
    • Organizer
      Human Brain Mapping 2011
    • Place of Presentation
      Quebeq, Canada
    • Year and Date
      2011-06-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Reduced high frequency gamma synchronization and auditory hallucination symptoms in schizophrenia2011

    • Author(s)
      Tsuchimoto R, et al
    • Organizer
      Human Brain Mapping 2011
    • Place of Presentation
      Quebec, Canada
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Auditory sensory gating deficit to voices in psychotic bipolar disorder : a MEG study2010

    • Author(s)
      Hirano Y, Hirano S, Oribe N, Maekawa T, Tsunoda T, Nakamura I, Tsuchimoto R, Ueno T, Ninomiya H, Onitsuka T, Kanba S
    • Organizer
      29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] 現代精神医学事典2011

    • Author(s)
      加藤敏ら編(分担:平野羊嗣)
    • Total Pages
      1400
    • Publisher
      弘文堂
    • Related Report
      2011 Final Research Report
  • [Book] 現代精神医学事典2011

    • Author(s)
      加藤敏, ら編(平野羊嗣:分担,編集協力者)
    • Total Pages
      1400
    • Publisher
      弘文堂
    • Related Report
      2011 Annual Research Report
  • [Book] 脳科学エッセンシャル-精神疾患の生物学的理解のために 専門医のための精神科臨床リュミエール16(分担):脳磁図と精神疾患2010

    • Author(s)
      平野羊嗣
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 脳科学エッセンシャル-精神疾患の生物学的理解のために.専門医のための精神科臨床リュミエール16 :脳磁図と精神疾患

    • Author(s)
      神庭重信ら編(分担:平野羊嗣)
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページ:(担当管理:平野羊嗣)

    • URL

      http://www.med.kyushu-u.ac.jp/psychiatry/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/psychiatry/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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