A study on the pathophysiology of pervasive developmental disorder and development of diagnostic support tool from a viewpoint of gender difference

• Project/Area Number: 22791133
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: TATENO Masaru 札幌医科大学, 医学部, 講師 (60464492)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 児童思春期精神医学 / 広汎性発達障害 / 自閉性障害 / アスペルガー障害 / 性差 / 心の理論 / 脳血流 / 神経栄養因子 / 神経幹細胞

Research Abstract

The Prisoner's Dilemma illustrates the paradoxical disposition of interaction between two individuals with opposing interests. We investigated the cognitive characteristics of Pervasive Developmental Disorder(PDD) by using a game based on this dilemma and demonstrated that the subjects with PDD had lower awareness to the others compared to the controls. Prenatal exposure to high dose ethanol causes various sequelae in the child including decreased social interaction. We performed transvenous transplantation of neural stem cells to the Fetal Alcohol Spectrum Disorders model rat and observed the improvement of the results of social interaction test. These results suggest that repair of neural network damage could be related to clinical symptoms in PDD.

Research Products

• [Journal Article] Does the 'hikikomori' syndrome of social withdrawal exist outside Japan? : A preliminary international investigation (2012)
  • Author(s): Takahiro A.Kato
  • Journal Title: Social Psychiatry and Psychiatric Epidemiology Volume: 47 Issue: 7 Pages: 1061-1075
  • DOI: 10.1007/s00127-011-0411-7
  • Peer Reviewed
• [Journal Article] Pervasive developmental disorders and autism spectrum disorders : are these disorders one and the same? (2011)
  • Author(s): Tateno M, Kikuchi S, Uehara K, et al.(全7人)
  • Journal Title: Psychiatry Investig Volume: 8 Pages: 67-70
  • Peer Reviewed
• [Journal Article] Does the' hikikomori' syndrome of social withdrawal exist outside Japan?: A preliminary international investigation Social (2011)
  • Author(s): Kato TA, Tateno M, Shinfuku N, et al.(全20人中2人目)
  • Journal Title: Psychiatry and Psychiatric Epidemiology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Introducing the concept of modern depression in Japan ; an international case vignette survey (2011)
  • Author(s): Kato TA, Shinfuku N, Fujisawa D, Tateno M, et al.(全22人中4人目)
  • Journal Title: J Affect Disord Volume: 135 Pages: 66-76
  • Peer Reviewed
• [Journal Article] Apolipoprotein E4 frequencies in a Japanese population with Alzheimer's disease and dementia with Lewy bodies (2011)
  • Author(s): Kobayashi S, Tateno M, Park TW, et al.(全8人中2人目)
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] 広汎性発達障害における性別違和に関する検討 (2011)
  • Author(s): 館農勝, 池田官司, 齋藤利和
  • Journal Title: 精神神経学雑誌 Volume: 113 Pages: 1173-1183
  • NAID: 10030969012
  • Peer Reviewed
• [Journal Article] アンケート調査に基づくひきこもりの精神医学的背景に関する検討 (2011)
  • Author(s): 館農勝, 佐々木竜二, 中野和歌子, 他(全8人)
  • Journal Title: 精神科 Volume: 18 Pages: 600-606
  • NAID: 40018832147
  • Peer Reviewed
• [Journal Article] FASDモデルに対する神経幹細胞移植療法の可能性神経回路再生と行動学的変化の解析 (2011)
  • Author(s): 白坂知彦, 鵜飼渉, 館農勝, 他(全10人中8人目)
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 46 Pages: 576-584
  • NAID: 10030198840
  • Peer Reviewed
• [Journal Article] Apolipoprotein E4 Frequencies in a Japanese Population with Alzheimer's Disease and Dementia with Lewy Bodies (2011)
  • Author(s): Kobayashi S
  • Journal Title: PLoS ONE Volume: 6 Issue: 4 Pages: e18569-e18569
  • DOI: 10.1371/journal.pone.0018569
  • Peer Reviewed
• [Journal Article] Pervasive developmental disorders and autism spectrum disorders : are these disorders one and the same? (2011)
  • Author(s): Masaru Tateno
  • Journal Title: Psychiatry Investigation Volume: 8 Issue: 1 Pages: 67-70
  • DOI: 10.4306/pi.2011.8.1.67
  • Peer Reviewed
• [Journal Article] Introducing the concept of modern depression in Japan ; an international case vignette survey (2011)
  • Author(s): Takahiro A.Kato
  • Journal Title: Journal of Affective Disorders Volume: 135 Issue: 1-3 Pages: 66-76
  • DOI: 10.1016/j.jad.2011.06.030
  • Peer Reviewed
• [Journal Article] 統合失調症入院患者に対する抗精神病薬処方の最近10年間の変化--東アジアにおける国際共同処方調査(REAP)の結果から (2011)
  • Author(s): 中野和歌子
  • Journal Title: 臨床精神薬理 Volume: 14 Pages: 1397-1411
  • Peer Reviewed
• [Journal Article] アンケー ト調査に基づくひきこもりの精神医学的背景に関する検討 (2011)
  • Author(s): 館農勝
  • Journal Title: 精神科 Volume: 18 Pages: 600-606
  • NAID: 40018832147
  • Peer Reviewed
• [Journal Article] 囚人のジレンマ型ゲームを用いた広汎性発達障害の認知特性の検討 (2011)
  • Author(s): 田山真矢
  • Journal Title: 精神科 Volume: 18 Pages: 464-469
  • Peer Reviewed
• [Journal Article] ストレスによる脳神経回路網変異～障害と修復の分子メカニズム～ (2010)
  • Author(s): 鵜飼渉, 橋本恵理, 館農勝, 他(全10人中8人目)
  • Journal Title: ストレス科学 Volume: 25 Pages: 167-177
  • Peer Reviewed
• [Journal Article] 囚人のジレンマ型ゲームを用いた広汎性発達障害の認知特性の検討 (2010)
  • Author(s): 田山真矢, 館農勝, 須見よし乃, 他(全7人中2人目)
  • Journal Title: 精神科 Volume: 18 Pages: 464-469
  • Peer Reviewed
• [Journal Article] Effect of antidepressants on brain-derived neurotrophic factor(BDNF) release from platelets in the rats (2010)
  • Author(s): Watanabe K, Hashimoto E, ... Tateno M, et al.(全11人中7人目)
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 34 Pages: 1450-1454
  • Peer Reviewed
• [Journal Article] Attitudes of early-career psychiatrists in Japan toward child and adolescent psychiatry and their career decision (2010)
  • Author(s): Masaru Tateno
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Pages: 199-201
  • Peer Reviewed
• [Journal Article] Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats (2010)
  • Author(s): Kimihiko Watanabe
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 34 Pages: 1450-1454
  • Peer Reviewed
• [Journal Article] Impact of biopsychosocial factors on psychiatric training in Japan and overseas : Are psychiatrists oriented to mind, brain, or sociocultural issues? (2010)
  • Author(s): Takahiro A Kato
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Pages: 520-530
  • Peer Reviewed
• [Journal Article] Liebowitz Social Anxiety Scale for Children and Adolescents日本語版の信頼性と妥当性の検討 (2010)
  • Author(s): 須見よし乃
  • Journal Title: 日本小児科学会雑誌 Volume: 114 Pages: 1185-1193
  • Peer Reviewed
• [Journal Article] レビー小体型認知症とアルツハイマー病におけるアポリタンパクE4の頻度 (2010)
  • Author(s): 小林清樹
  • Journal Title: 老年精神医学雑誌 Volume: 21 Pages: 253-260
  • Peer Reviewed
• [Journal Article] 不安の病理と治療の今日的展開 物質依存と不安 (2010)
  • Author(s): 館農勝
  • Journal Title: 臨床精神医学 Volume: 39 Pages: 421-424
• [Presentation] 総合病院での不登校・ひきこもりへの対応 (2011)
  • Author(s): 館農勝
  • Organizer: 第24回日本総合病院精神医学会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2011-11-25
• [Presentation] 青年期アスペルガー障害のジレンマ状況における意思決定過程に関する検討 (2011)
  • Author(s): 田山真矢, 館農勝, 須見よし乃, 他(全5人中2番目)
  • Organizer: 第52回日本児童青年精神医学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2011-11-12
• [Presentation] Antidepressant-induce platelet BDNF release : implication to the neurogenesis dysfunction in Depression (2011)
  • Author(s): Wataru Ukai
  • Organizer: Society for Neuroscience 41th Annual Meeting
  • Place of Presentation: ワシントンD.C.(米国)
  • Year and Date: 2011-11-12
• [Presentation] The effect of antipsychotics on interneurogenesis of adult neural stem cells (2011)
  • Author(s): Kaneta Hiroo
  • Organizer: Society for Neuroscience 41th Annual Meeting
  • Place of Presentation: ワシントンD.C.(米国)
  • Year and Date: 2011-11-12
• [Presentation] 海外児童精神科医を対象としたひきこもりの精神医学的背景に関するケース・ビネット調査 (2011)
  • Author(s): 館農勝
  • Organizer: 第52回日本児童青年精神医学会総会
  • Place of Presentation: あわぎんホール(徳島)
  • Year and Date: 2011-11-10
• [Presentation] ひきこもりの精神医学的診断について～海外学術誌に掲載されたCase vignetteを用いたインターネット上の国際症例検討会の結果から～ (2011)
  • Author(s): 館農勝
  • Organizer: 第107回日本精神神経学会学術総会
  • Place of Presentation: グランパシフィック(東京)
  • Year and Date: 2011-10-26
• [Presentation] 神経幹細胞移植を用いた社会認識行動の再生～FASDモデルラットを用いた考察～ (2011)
  • Author(s): 白坂知彦, 鵜飼渉...館農勝, 他(全10人中8人目)
  • Organizer: アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] Hikikomori as a clinical concept in psychiatry (2011)
  • Author(s): Masaru Tateno
  • Organizer: 15th World Congress of Psychiatry
  • Place of Presentation: ブエノスアイレス(アルゼンチン)
  • Year and Date: 2011-09-18
• [Presentation] Stem cell therapy : A novel treatment strategy for fetal alcohol spectrum disorder (2011)
  • Author(s): Toshikazu Saito
  • Organizer: 34th Annual Scientific Meeting of the Research Society on Alcoholism
  • Place of Presentation: アトランタ(米国)
  • Year and Date: 2011-06-25
• [Presentation] Potential regulation of neurogenesis by antidepressant/stem cell transplantation in alcohol-induced brain damage (2011)
  • Author(s): Eri Hashimoto
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2011-05-29
• [Presentation] Alcoholism/depression : Biological markers in psychiatric disorders (2011)
  • Author(s): Toshikazu Saito
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: プラハ(チェコ)(招待講演)
  • Year and Date: 2011-05-29
• [Presentation] 統合失調症の脳神経回路修復-薬物・細胞コンバインド療法の可能性の検討 (2011)
  • Author(s): 鵜飼渉
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: グランパシフィック(東京)
  • Year and Date: 2011-05-21
• [Presentation] 神経幹細胞移植によるFASDモデルラット「社会脳」再生の試み (2011)
  • Author(s): 白坂知彦, 鵜飼渉...館農勝, 他(全10人中8人目)
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] A comparison of Child and Adolescent Psychiatry in four Asian countries (2010)
  • Author(s): Noor A Giasuddin
  • Organizer: 2nd HK-UK International Conference
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2010-11-12
• [Presentation] ゲーム理論を用いた自閉症スペクトラムの協力行動に関する検討 (2010)
  • Author(s): 田山真矢, 館農勝, 須見よし乃, 他(全5人中2人目)
  • Organizer: 第51回日本児童青年精神医学会総会
  • Place of Presentation: 前橋
  • Year and Date: 2010-10-30
• [Presentation] 核内レセプターTLXの神経幹細胞における働きと抑肝散の与える影響 (2010)
  • Author(s): 渡邉一平
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: リーガロイヤルホテル小倉(福岡県)
  • Year and Date: 2010-10-08
• [Presentation] 末梢BDNFの脳内移行に関する検討 (2010)
  • Author(s): 渡邊公彦
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: リーガロイヤルホテル小倉(福岡県)
  • Year and Date: 2010-10-08
• [Presentation] Stem cell regulation as a new treatment strategy for alcoholism and other psychiatric disorders (2010)
  • Author(s): Saito T, Hashimoto E, Tateno M, et al.
  • Organizer: The 15th International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Paris, France
  • Year and Date: 2010-09-15
• [Presentation] Alcohol induced neurogenetic dysfunction : Roles of transcription factors and epigenetic regulation (2010)
  • Author(s): Wataru Ukai
  • Organizer: International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Paris, France
  • Year and Date: 2010-09-14
• [Presentation] Stem cell regulation as a new treatment strategy for alcoholism and other psychiatric disorders (2010)
  • Author(s): Toshikazu Saito
  • Organizer: International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Paris, France
  • Year and Date: 2010-09-14
• [Presentation] Stem cell therapy-social function recovery in FASD model (2010)
  • Author(s): Tomohiro Shirasaka
  • Organizer: International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Paris, France
  • Year and Date: 2010-09-14
• [Presentation] 末梢BDNFの体内動態を解明する (2010)
  • Author(s): 渡邊公彦
  • Organizer: 第29回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 箱根湯本(神奈川県)
  • Year and Date: 2010-06-18
• [Presentation] Stem cell therapy-functional recovery in a neurodevelopmental model of schizophrenia (2010)
  • Author(s): Eri Hashimoto
  • Organizer: Collegium Internationale Neuro-Psychopharmacologicum
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2010-06-07
• [Presentation] Roles of nuclear receptor TLX in neural stem cell functions (2010)
  • Author(s): Ippei Watanabe
  • Organizer: Collegium Internationale Neuro-Psychopharmacologicum
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2010-06-07
• [Presentation] The change of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor on platelet in depression (2010)
  • Author(s): Kimihiko Wantanabe
  • Organizer: Collegium Internationale Neuro-Psychopharmacologicum
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2010-06-07
• [Presentation] The International Psychiatry Resident/Trainee Burnout Syndrome Study (2010)
  • Author(s): Nikolina Jovanovic
  • Organizer: The 18th European Federation of Psychiatric Trainees forum
  • Place of Presentation: Dubrovnik, Croatia
  • Year and Date: 2010-06-03
• [Presentation] Potential regulation of neurogenesis by antidepressant/stem cell transplantation in alcohol-induced brain damage (2010)
  • Author(s): Hashimoto E, Ukai W…Tateno M, et al.(全10人中9人目)
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2010-05-30