Predicting plasma concentration of risperidone associated with dosage change : a population pharmacokinetic study

• Project/Area Number: 22791140
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Keio University
• Principal Investigator: UCHIDA Hiroyuki 慶應義塾大学, 医学部, 助教 (40327630)
• Research Collaborator: BIES Robert R. Indiana University School of Medicine, Division of Clinical Pharmacology, 准教授 ; MAMO David University of Toronto, Department of Psychiatry, 准教授
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 血中濃度 / 抗精神病薬 / 統合失調症 / 血中動態 / ドパミン / 予測

Research Abstract

The present study, including50patients with schizophrenia, demonstrated that antipsychotic plasma concentrations of risperidone and its active moiety can be predicted before performing an actual dosage change, using population pharmacokinetic techniques. These findings suggest that individualized dosing with the measurement of antipsychotic plasma concentrations could become a real clinical application in the management of schizophrenia.

Research Products

• [Journal Article] Dopamine D2receptor occupancy and cognition in schizophrenia : analysis of the CATIE data (2012)
  • Author(s): Sakurai H, Bies RR, Stroup SE, Keefe RSE, Rajji TK, Suzuki T, Mamo DC, Pollock BG, Watanabe K, Mimura M, Uchida H
  • Journal Title: Schizophr Bull Volume: (in press)
  • Peer Reviewed
• [Journal Article] Therapeutic window for striatal dopamine D2/3receptor occupancy in older patients with schizophrenia : a pilot PET study (2012)
  • Author(s): Uchida H, Suzuki T, Graff-Guerrero A, Mulsant BH, Pollock BG, Arenovich T, Rajji TK, Mamo DC
  • Journal Title: Am J Geriatr Psychiatry Volume: (in press)
  • Peer Reviewed
• [Journal Article] A cross-sectional study of plasma risperidone levels with risperidone long-acting injectable : Implications for dopamine D2receptor occupancy during maintenance treatment in schizophrenia (2012)
  • Author(s): Ikai S, Remington G, Suzuki T, Takeuchi H, Tsuboi T, Den R, Hirano J, Tsunoda K, Nishimoto M, Watanabe K, Mimura M, Mamo DC, Uchida H
  • Journal Title: J Clin Psychiatry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Dopamine D2receptor occupancy with risperidone or olanzapine during maintenance treatment of schizophrenia : a cross-sectional study (2012)
  • Author(s): Mizuno Y, Bies RR, Remington G, Mamo DC, Suzuki T, Pollock BG, Tsuboi T, Watanabe K, Mimura M, Uchida H
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 37 Pages: 182-7
  • Peer Reviewed
• [Journal Article] Predicting plasma concentration of risperidone associated with dosage change : a population pharmacokinetic study. (2012)
  • Author(s): Uchida H, Mamo DC, Pollock BG, Suzuki T, Tsunoda K, Watanabe K, Mimura M, Bies RR
  • Journal Title: Therapeut Drug Monit Volume: 34 Pages: 182-7
  • Peer Reviewed
• [Journal Article] Dopamine D_2 receptor occupancy with risperidone or olanzapine during maintenance treatment of schizophrenia : a cross-sectional study (2012)
  • Author(s): Mizuno Y, Bies RR, Remington G, Mamo DC, Suzuki T, Pollock BG, Tsuboi T, Watanabe K, Mimura M, Uchida H
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 37 Issue: 1 Pages: 182-187
  • DOI: 10.1016/j.pnpbp.2011.12.013
  • Peer Reviewed
• [Journal Article] Predicting plasma concentration of risperidone associated with dosage change : a population pharmacokinetic study (2012)
  • Author(s): Uchida H, Mamo DC, Pollock BG, Suzuki T, Tsunoda K, Watanabe K, Mimura M, Bies RR
  • Journal Title: Therapeut Drug Monit Volume: 34 Issue: 2 Pages: 182-187
  • DOI: 10.1097/ftd.0b013e3182489a6f
  • Peer Reviewed
• [Journal Article] Dopamine D2 receptor occupancy and cognition in schizophrenia : analysis of the CATIE data (2012)
  • Author(s): Sakurai H, Bies RR, Stroup SE, Keefe RSE, Rajji TK, Suzuki T, Mamo DC, Pollock BG, Watanabe K, Mimura M, Uchida H
  • Journal Title: Schizophr Bull Volume: (印刷中) Issue: 3 Pages: 564-574
  • DOI: 10.1093/schbul/sbr189
  • Peer Reviewed
• [Journal Article] Therapeutic window for striatal dopamine D2/3 receptor occupancy in older patients with schizophrenia : a pilot PET study (2012)
  • Author(s): Uchida H, Suzuki T, Graff-Guerrero A, Mulsant BH, Pollock BG, Arenovich T, Rajji TK, Mamo DC.
  • Journal Title: Am J Geriatr Psychiatry Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Predicting dopamine D2receptor occupancy from plasma levels of antipsychotic drugs : a Systematic Review and Pooled Analysis (2011)
  • Author(s): Uchida H, Takeuchi H, Graff-Guerrero A, Suzuki T, Watanabe K, Mamo DC
  • Journal Title: J Clin Psychopharmacology Volume: 31 Pages: 318-325
  • Peer Reviewed
• [Journal Article] Dopamine D2receptor occupancy and clinical effects : a systematic review and pooled analysis (2011)
  • Author(s): Uchida H, Takeuchi H, Graff-Guerrero A, Suzuki T, Watanabe K, Mamo DC
  • Journal Title: J Clin Psychopharmacology Volume: 31 Pages: 497-502
  • Peer Reviewed
• [Journal Article] A Tipping Point in Drug Dosing in Late-Life (2011)
  • Author(s): Tsuboi T, Suzuki T, Uchida H
  • Journal Title: Current Psychiatry Reports Volume: 13 Pages: 225-33
• [Journal Article] Predicting dopamine D2 receptor occupancy from plasma levels of antipsychotic drugs : a Systematic Review and Pooled Analysis (2011)
  • Author(s): Uchida H, Takeuchi H, Graff-Guerrero A, Suzuki T, Watanabe K, Mamo DC
  • Journal Title: J Clin Psychopharmacology Volume: 31 Issue: 3 Pages: 318-325
  • DOI: 10.1097/jcp.0b013e318218d339
  • Peer Reviewed
• [Journal Article] Dopamine D_2 receptor occupancy and clinical effects : a systematic review and pooled analysis (2011)
  • Author(s): Uchida H, Takeuchi H, Graff-Guerrero A, Suzuki T, Watanabe K, Mamo DC
  • Journal Title: J Clin Psychopharmacology Volume: 31 Issue: 4 Pages: 497-502
  • DOI: 10.1097/jcp.0b013e3182214aad
  • Peer Reviewed
• [Journal Article] A tipping point in drug dosing in late-life (2011)
  • Author(s): Tsuboi T, Suzuki T, Uchida H
  • Journal Title: Current Psychiatry Reports Volume: 13 Issue: 3 Pages: 225-233
  • DOI: 10.1007/s11920-011-0189-z
• [Journal Article] Predicting Dopamine D2 Receptor Occupancy from Plasma Levels of Antipsychotic Drugs : A Systematic Review and Pooled Analysis (2011)
  • Author(s): Uchida H, Takeuchi H, Graff-Guerrero A, Suzuki T, Watanabe K, Mamo DC
  • Journal Title: J Clin Psychopharmacology Volume: 33 Pages: 318-325
  • Peer Reviewed
• [Journal Article] Dopamine D2 Receptor Occupancy and Clinical Effects : A Systematic Review and Pooled Analysis (2011)
  • Author(s): Uchida H, Takeuchi H, Graff-Guerrero A, Suzuki T, Watanabe K, Mamo DC
  • Journal Title: J Clin Psychopharmacology Volume: (in press)
  • Peer Reviewed
• [Presentation] 処方変更後の抗精神病薬の血中濃度を予測する試み (2011)
  • Author(s): 内田裕之, Mamo DC, Pollock BG, 鈴木健文, 竹内啓善、野村健介、角田健一、渡邊衡一郎, Bies RR
  • Organizer: 第21回日本臨床精神薬理学会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-28
• [Presentation] 処方変更後の抗精神病薬の血中濃度を予測する試み (2011)
  • Author(s): 内田裕之, Mamo DC, Pollock BG, 鈴木健文, 竹内啓善、野村健介、角田健一、渡邊衡一郎, Bies RR
  • Organizer: 第21回日本臨床精神薬理学会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 2011-10-28
• [Presentation] Predicting Antipsychotic Plasma Concentrations Before Titrating The Dose : A Population Pharmacokinetic Study (2010)
  • Author(s): Uchida H, Mamo DC, Pollock BG, Mulsant BH, Suzuki T, Watanabe K, Bies RR
  • Organizer: 10th biannual meeting of Australian Schizophrenia Conference
  • Place of Presentation: Sydney
  • Year and Date: 2010-09-22
• [Presentation] 処方変更後のリスペリドン血中濃度を予測する試み: Population Pharmacokineticsを用いて (2010)
  • Author(s): 内田裕之, Mamo DC, Pollock BG, Mulsant BH, 鈴木健文, 渡邊衡一郎, Bies RR
  • Organizer: 第20回日本臨床精神薬理学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-16
• [Presentation] 処方変更後のリスペリドン血中濃度を予測する試み:Population Pharmacokineticsを用いて (2010)
  • Author(s): 内田裕之, Mamo DC, Pollock BG, Mulsant BH, 鈴木健文, 渡邊衡一郎, Bies RR
  • Organizer: 第20回日本臨床精神薬理学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-16