Thought disorder in schizophrenia on functional MRI study
| Project/Area Number |
22791143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Tamagawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 統合失調症 / fMRI / 思考障害 / 自動処理 / 大脳基底核 / 自己認知 / セルフリフレクション |
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| Research Abstract |
Efforts to localize neural activity associated with self-and other-referential processing have described the activity in the medial prefrontal cortex(mPFC), the anterior cingulate cortex(ACC), and the anterior insula for self-versus other-referencing and activity in the precuneus for other-versus self-referencing. We therefore explored differences in brain activity between patients with schizophrenia and normal controls using functional magnetic resonance imaging(fMRI). Normal controls showed higher activation of the anterior insula, which is associated with self-reflection, whereas patients with schizophrenia showed higher activation of the precuneus, an area associated with other-reflection, even though they were contemplating the correctness of their own answers. These results indicate that patients with schizophrenia may perceive themselves not as self but as other, even during tasks requiring them to reflect on themselves.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity2011
Author(s)
Marutani, T., Yahata, N., Ikeda, Y., Ito, T., Yamamoto, M., Matsuura, M., Okubo, Y., Matsushima, E., Suzuki, H. & Matsuda, T.
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Journal Title
Psychiatry Clin Neurosci
Volume: 65
Issue: 2
Pages: 191-198
DOI
Related Report
Peer Reviewed
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[Presentation] Dysfunction of self-reflection in schizophrenia : A functional MRI study2011
Author(s)
Matsuda T, Takahashi S, Nemoto Y, Suzuki M, Ito T, Yamamoto M, Marutani T, Takahashi H, Matsuura M, Matsushima E, Uchiyama M, Kojima T
Organizer
American Psychiatric Association
Place of Presentation
Hawaii
Year and Date
2011-05-16
Related Report
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