The effects of exercise on neuroimaging and psychopharmacological study in depression
| Project/Area Number |
22791150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
SUGITA Atsuko 産業医科大学, 医学部, 講師 (40421333)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | うつ病 / 運動療法 / ウォーキング / 成長因子 / 一酸化窒素代謝動態 / 一酸化窒素代謝産物動態 |
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| Research Abstract |
We examined the pharmacological mechanisms of exercise on depression. This study included 12 patients with depression in our university hospital and 36 healthy controls. Ham-D and SDS score were significantly decreased after 8-week exercise in the patients with depression. Exercise significantly increased NOx (P<0.05) and MHPG (P<0.01), but not BDNF, HVA, blood biochemical exam, blood pressure, body mass index and west in depression. We assessed MRI and SPECT only one patient with depression. The cerebral blood flow with the patient was improved after the exercise. There were no associations between improvement of depression and the levels of BDNF, NOx, MHPG, HVA in before exercise. Exercise significantly decreased HVA (P<0.05), but not BDNF, NOx, MHPG, blood biochemical exam, blood pressure, body mass index and west in control. We cannot assess MRI and SPECT on healthy control.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan2011
Author(s)
Okuno K, Yoshimura R, Ueda N, Ikenouchi-Sugita A, Umene-Nakano W, Hori H, Hayashi K, Katsuki A, Chen HI, Nakamura J
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Journal Title
Psychiatry Res
Volume: 186
Pages: 326-32
Related Report
Peer Reviewed
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[Journal Article] 気分障害とBDNF2010
Author(s)
吉村玲児, 杉田篤子, 堀輝, 中野和歌子, 香月あすか, 林健司, 阿竹聖和, 上田展久, 中村純
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Journal Title
日本神経精神薬理学雑誌
Volume: 30
Pages: 181-184
NAID
Related Report
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