Search for biomarkers of bipolar disorder

• Project/Area Number: 22791152
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: KAZUNO An-a 独立行政法人理化学研究所, 精神疾患動態研究チーム, リサーチアソシエイト (40360523)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脳神経疾患 / 双極性障害 / バイオマーカー

Research Abstract

To search for biomarker of bipolar disorder, we extracted proteins derived from lymphoblastoid cells of monozygotic twins discordant for bipolar disorder and compared protein levels between patients with bipolar disorder and co-twin using two-dimensional fluorescence difference gel electrophoresis. Using antibodies against a part of proteins identified, we performed the case-control study by using western blot analysis. We identified a glycolysis related protein that is different expression levels between patients and healthy controls. The protein may be a biomarker of bipolar disorder.

Research Products

• [Journal Article] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins (2011)
  • Author(s): Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno AA, Adati N, Kusumi I, Okazaki Y, Ishigooka J, Kojima T, Kato T
  • Journal Title: Translational Psychiatry Volume: 1
• [Journal Article] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins (2011)
  • Author(s): Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusumi I, Okazaki Y, Ishigooka J, Koji-ma T, Kato T
  • Journal Title: Translational Psychiatry Volume: 1 Issue: 7 Pages: e24-e24
  • DOI: 10.1038/tp.2011.26
  • Peer Reviewed
• [Presentation] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins (2012)
  • Author(s): Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusum I, Okazaki Y, Ishigooka J, Kojima T, Kato T
  • Organizer: 5th Biennial Conference of the International Society for Bipolar Disorders
  • Place of Presentation: Turkey, Istanbul
  • Year and Date: 2012-03-15
• [Presentation] 一卵性双生児双極性障害不一致例におけるリンパ芽球由来ミトコンドリアのプロテオミクス解析 (2011)
  • Author(s): 数野安亜、岡崎祐士、加藤忠史
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] 一卵性双生児双極性障害不一致例におけるゲノム差異およびエピゲノム差異の探索 (2011)
  • Author(s): 菅原裕子、岩本和也、文東美紀、上田順子、宮内妙子、小森敦子、数野安亜、足立直樹、久住一郎、岡崎祐士、石郷岡純、小島俊男、加藤忠史
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] Mitochondrial proteomic analysis of lymphoblastoid cells derived from patients with bipolar disorder (2010)
  • Author(s): Kazuno A, Okazaki Y, Kato T
  • Organizer: XVIII World Congress on Psychiatric Genetics
  • Place of Presentation: Greece, Athens
  • Year and Date: 2010-10-05
• [Presentation] Mitochondrial proteomic analysis of lymphoblastoid cells derived from patients with bipolar disorder (2010)
  • Author(s): An-a Kazuno
  • Organizer: XVIII World congress for Psychiatric Genetics
  • Place of Presentation: Athens
  • Year and Date: 2010-10-05
• [Remarks]
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