Transport Response in mammalian young: Analysis of neuromolecular mechanism

• Project/Area Number: 22791153
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YOSHIDA Sachine 独立行政法人理化学研究所, 黒田研究ユニット, 研究員 (90513458)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: マウス / 輸送反応 / 生後発達 / 親子関係 / 愛着行動 / トランスポートレスポンス

Research Abstract

A mother carries the young in many altricial mammals. Meanwhile, the transported young immediately assume a compact posture and stay calm. This young's response to maternal transport is called "Transport Response (TR)". We studied the postnatal development and regulatory mechanisms of TR using mouse pups. We found that TR was an intricate combination of immobilization and postural regulation. Tactile sensation and proprioception were essential for immobilization component of TR. The postural regulation component of TR was dependent on the cerebellar function. These findings indicate that TR is a filial-specific response that involves multiple brain areas for its regulation.

Research Products

• [Journal Article] Infant calming responses during maternal carrying in humans and mice (2013)
  • Author(s): Gianluca Esposito, Sachine Yoshida (equal contribution)
  • Journal Title: Current Biology Volume: 23 Issue: 9 Pages: 1-7
  • DOI: 10.1016/j.cub.2013.03.041
  • Peer Reviewed
• [Journal Article] Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse (2013)
  • Author(s): Yousuke Tsuneoka
  • Journal Title: Journal of Comparative Neurology Volume: 521 Issue: 7 Pages: 1633-1663
  • DOI: 10.1002/cne.23251
  • Peer Reviewed
• [Journal Article] Vesicular glutamate transporter 2 expression in the rat pineal gland: Detailed analysis of expression pattern and regulatory mechanism (2012)
  • Author(s): Yoshida S, Hisano S
  • Journal Title: Kansei Eng. Int. J Volume: 11 Pages: 133-137
  • NAID: 130002148649
• [Journal Article] A rhythmic change of vesicular glutamate transporter (VGLUT) 2 expression in the rat pineal gland (2012)
  • Author(s): Yoshida S, Hira Y, Ehara A, Mimura-Yamamoto Y, Kawano M, Shutoh F, Nogami H, Hisano S
  • Journal Title: Neurosci. Res Volume: 72 Pages: 16-22
• [Journal Article] Three lessons from Philip TeitelLbaum and their application to tudies of motor development in humans and mice (2012)
  • Author(s): Esposito G, Yoshida S, Venuti P, Kuroda. KO
  • Journal Title: Behav. Brain Res. Volume: 23 Pages: 366-370
• [Journal Article] Vesicular glutamate transporter 2 expression in the rat pineal gland: Detailed analysis of expression pattern and regulatory mechanism (2012)
  • Author(s): Sachine Yoshida
  • Journal Title: Kansei Engineering International Journal Volume: 11 Pages: 133-137
  • NAID: 130002148649
  • Peer Reviewed
• [Journal Article] A rhythmic change of vesicular glutamate transporter (VGLUT) 2 expression in the rat pineal gland (2012)
  • Author(s): Sachine Yoshida
  • Journal Title: Neuroscience Research Volume: 72 Issue: 1 Pages: 16-22
  • DOI: 10.1016/j.neures.2011.09.008
  • Peer Reviewed
• [Journal Article] Three lessons from Philip Teitelbaum and their application to studies of motor development in humans and mice (2012)
  • Author(s): Gianluca Esposito
  • Journal Title: Behavioural Brain Research Volume: 23 Issue: 2 Pages: 366-370
  • DOI: 10.1016/j.bbr.2011.10.008
  • Peer Reviewed
• [Journal Article] Temporally distinct expression of vesicular glutamate transporters 1 and 2 during embryonic development of the rat olfactory system (2011)
  • Author(s): Ohmomo H, Ehara A, Yoshida S, Shutoh F, Ueda S, Hisano S
  • Journal Title: Neurosci. Res. Volume: 70 Pages: 376-382
• [Journal Article] Neuromolecular basis of parental behavior in laboratory mice and rats : With special emphasis on technical issues of using mouse genetics (2011)
  • Author(s): Kuroda KO, Tachikawa K, Yoshida S, Tsuneoka Y, Numan M
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry Volume: 35 Issue: 5 Pages: 1205-1231
  • DOI: 10.1016/j.pnpbp.2011.02.008
  • Peer Reviewed
• [Journal Article] Infant calming responses during maternal carrying in humans and mice
  • Author(s): Esposito G#, Yoshida S#, Ohnishi R, Tsuneoka Y, Rostango M,Yokota S, Okabe S, Kamiya K, Hoshino M, Shimizu M, Venuti P, Kikusui T, Kato T, Kuroda KO
  • Journal Title: Current Biol Volume: (Accepted)
• [Journal Article] Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse
  • Author(s): Tsuneoka Y, Maruyama T, Yoshida S, Nishimori K, Kato T, Numan M, Kuroda KO
  • Journal Title: J. Comp. Neurol Volume: (in press)
• [Presentation] 仔マウスが親に運ばれる時に示す輸送反応へ及ぼす母子分離ストレスの影響 (2012)
  • Author(s): 吉田さちね、Gianluca Esposito、恒岡洋右、菊水健史、加藤忠史、黒田公美
  • Organizer: 第39回日本神経内分泌学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 仔マウスが親に運ばれる時に示す輸送反応の発達とその制御機構 (2012)
  • Author(s): 吉田さちね、Gianluca Esposito、恒岡洋右、大西竜子、神谷和作、星野幹雄、菊水健史、加藤忠史、黒田公美
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 愛知
• [Presentation] 仔マウスが親に運ばれる時に示す輸送反応へ及ぼす母子分離ストレスの影響 (2012)
  • Author(s): 吉田さちね
  • Organizer: 第39回日本神経内分泌学会学術集会
  • Place of Presentation: 北九州国際会議場
• [Presentation] 仔マウスが親に運ばれる時に示す輸送反応の発達とその制御機構 (2012)
  • Author(s): 吉田さちね 第35回日本神経科学大会、愛知、2012.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 仔マウスが運ばれる時に示す輸送反応の研究:制御機構と愛着形成への関与の検討 (2011)
  • Author(s): 吉田さちね、黒田公美
  • Organizer: 第13回日本感性工学会大会
  • Place of Presentation: 工学院大学(東京)(招待講演)
  • Year and Date: 2011-09-03
• [Presentation] 仔マウスの輸送反応の解析 (2011)
  • Author(s): 吉田さちね
  • Organizer: 行動神経内分泌研究会
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2011-02-08
• [Presentation] 仔マウスが運ばれる時に示す輸送反応の解析 : 制御機構と愛着行動としての可能性 (2011)
  • Author(s): 吉田さちね、恒岡洋右、大西竜子、菊水健史、加藤忠史、黒田公美
  • Organizer: Animal 2011
  • Place of Presentation: 東京
• [Presentation] 仔マウスが運ばれる時に示す輸送反応の研究 : 制御機構と愛着形成への関与の検討 (2011)
  • Author(s): 吉田さちね、黒田公美
  • Organizer: 第13回日本感性工学会大会
  • Place of Presentation: 東京
• [Presentation] 仔マウスが運ばれる時に示す輸送反応の解析:制御機構と愛着行動としての可能性 (2011)
  • Author(s): 吉田さちね、恒岡洋右、大西竜子、菊水健史、加藤忠史、黒田公美
  • Organizer: Animal 2011
  • Place of Presentation: 慶応大学(東京)(招待講演)
• [Presentation] The ontogeny and the regulatory mechanism of transport response in mouse pups (2010)
  • Author(s): 吉田さちね
  • Organizer: Parental Brain
  • Place of Presentation: University of Edinburgh (Edinburgh)
  • Year and Date: 2010-09-03
• [Presentation] The ontogeny and the regulatory mechanism of transport response in mouse pups (2010)
  • Author(s): Yoshida S, Tsuneoka Y, Kikusui T, Kato T, Kuroda KO
  • Organizer: The 4^<th> International conference on The Parental Brain
  • Place of Presentation: Edinburgh
• [Book] New Developments in Melatonin Research (2013)
  • Author(s): Sachine Yoshida
  • Publisher: Nova Publisher
• [Book] Diurnal expression of vesicular glutamate transporters in the rat pineal gland and its relationship to melatonin secretion, In : New Developments in Melatonin Research. (Acuna-Castroviejo D (ed))
  • Author(s): Yoshida S, Nogami H, Hisano S
  • Publisher: Nova Publisher, New York (in press)
• [Remarks]
  • URL: http://asb.brain.riken.jp/index.html
• [Remarks] 理化学研究所 脳科学総合研究センター 黒田親和性社会行動研究ユニット
  • URL: http://asb.brain.riken.jp/index.html
• [Remarks] 理化学研究所 報道発表資料
  • URL: http://www.riken.go.jp/pr/press/2013/20130419_2/
• [Remarks]
  • URL: http://asb.brain.riken.jp/index.html
• [Remarks]
  • URL: http://asb.brain.riken.jp/index_j.html