Understanding the pathology of epilepsy through the regulation of endoplasmic reticulum calcium homeostasis

Research Project

Project/Area Number	22791154
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Psychiatric science
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	SUZUKI Toshimitsu 独立行政法人理化学研究所, 神経遺伝研究チーム, 研究員 (20373318)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	てんかん / EFHC1 / IP3レセプター / 小胞体カルシウム / IP_3レセプター
Research Abstract	We found that myoclonin1 modulates ER-Ca^<2+> homeostasis through interaction with C-terminal of IP_3R1.Our results suggest that impaired intracellular Ca^<2+> mobilization may be the molecular basis for epilepsy caused by EFHC1 mutations.

Report

(3 results)