Brain aromatase and aggression: Human PET study

• Project/Area Number: 22791155
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TAKAHASHI Kayo 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (90462697)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: aromatase / human / PET / aggression / temperament and character / estrogen / emotion / hypothalamus / thalamus / amygdala / Aromatase / Emotion / Estrogen

Research Abstract

A PET probe for aromatase imaging named [^<11>C]cetrozole was newly developed in order to measure quantitatively aromatase in human brain. The pharmacokinetics and dynamics of [^<11>C]cetrozole were defined in animal experiments, and then the PET probe was administered in living human. Healthy subjects were asked to answer questionnaires to measure their aggression, temperament and character. The regression analysis showed positive correlation between aromatase level in the thalamus and the score for aggression and also positive correlation between aromatase level in the hypothalamus and the score for empathy. This study may clarify the relationship between aromatase and human character, emotion, or mood.

Research Products

• [Journal Article] Practical synthesis of precursor of [N-methyl-^<11>C]vorozole, an efficient PET tracer targeting aromatase in the brain (2011)
  • Author(s): Takahashi K, Yamagishi G, Hiramatsu T, Hosoya A, Onoe K, Doi H, Nagata H, Wada Y, Onoe H, Watanabe Y, Hosoya T
  • Journal Title: Bioorganic and Medicinal Chemistry 2011 Volume: 19 Pages: 1464-1470
  • Peer Reviewed
• [Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic androgenic steroids: PET study with [^<11>C]vorozole (2011)
  • Author(s): Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergstrom M, Onoe H, Langstrom B, Watanabe Y
  • Journal Title: NeuroReport Volume: 22 Pages: 326-330
  • Peer Reviewed
• [Journal Article] Practical synthesis of precursor of [N-methyl-^<11>C]vorozole, an efficient PET tracer targeting aromatase in the brain. (2011)
  • Author(s): Takahashi K
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 19 Pages: 1464-70
  • Peer Reviewed
• [Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic androgenic steroids : PET study with [^<11>C]vorozole. (2011)
  • Author(s): Takahashi K
  • Journal Title: NeuroReport Volume: (in press)
  • Peer Reviewed
• [Presentation] Aromatase imaging in human brain (2012)
  • Author(s): 高橋佳代
  • Organizer: The 14^<th> International Conference : Peach through Mind Brain Science
  • Place of Presentation: 浜松(招待講演)
  • Year and Date: 2012-02-14
• [Presentation] Aromatase distribution in human brain demonstrated by PET with [11C]cetrozole (2012)
  • Author(s): Takahashi K, Hosoya T, Takashima T, Tanaka M, Ishii A, Nakatomi Y, Tazawa S, Takahashi K, Doi H, Watanabe Yu, Wada Y, Suzuki M, Onoe H, Watanabe Y
  • Organizer: 42nd Annual Meeting of Society for Neuroscience, New Orleans
  • Place of Presentation: LA, USA
• [Presentation] PETを用いたヒト脳aromatase のイメージング (2012)
  • Author(s): 高橋 佳代、細谷 孝充、高島 忠之、田中雅彰、石井 聡、中富 康仁、田沢周作、高橋 和弘、土居 久志、渡辺 由美子、和田 康弘、鈴木 正昭、尾上 浩隆、渡辺 恭良
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Imaging brain aromatase in human with [^<11>C]cetrozole (2012)
  • Author(s): Takahashi K, Hosoya T, Takashima T, Tanaka M, Ishii A, Nakatomi Y, Tazawa S, Takahashi K, Doi H, Watanabe Yu, Wada Y, Suzuki M, Onoe H, Watanabe Y
  • Organizer: 2012 World Molecular Imaging Congress
  • Place of Presentation: Dublin, Ireland
• [Presentation] Aromatase imaging in human brain (2012)
  • Author(s): Takahashi, K
  • Organizer: The 14^<th> International Conference : Peace through Mind Brain Science
  • Place of Presentation: Hamamatsu, Japan
• [Presentation] PETを用いたヒト脳aromataseのイメージング (2012)
  • Author(s): 高橋佳代
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Imaging brain aromatase in human with [11C]cetrozole (2012)
  • Author(s): Kayo Takahashi
  • Organizer: 2012 World Molecular Imaging Congress
  • Place of Presentation: Dublin, Ireland
• [Presentation] Aromatase distribution in human brain demonstrated by PET with [11C]cetrozole (2012)
  • Author(s): Kayo Takahashi
  • Organizer: 42nd Annual Meeting of Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Presentation] 新規aromataseイメージングPETプローブ (2011)
  • Author(s): 高橋佳代
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2011-05-26
• [Presentation] Aromatase imaging for emotional and affective disorders (2011)
  • Author(s): 高橋佳代
  • Organizer: The 7^<th> Uppsala Spring Meeting 2011
  • Place of Presentation: Uppsala, Sweden(招待講演)
  • Year and Date: 2011-04-14
• [Presentation] 新規aromatase イメージングPETプローブ (2011)
  • Author(s): 高橋佳代、細谷孝充、尾上嘉代、長田浩子、土居久志、和田康弘、高島忠之、田村泰久、渡辺由美子、田中雅彰、石井聡、鈴木正昭、尾上浩隆、渡辺恭良
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Aromatase imaging for emotional and affective disorders (2011)
  • Author(s): Takahashi, K
  • Organizer: The 7^<th> Uppsala Spring Meeting 2011
  • Place of Presentation: Uppsala, Sweden
• [Presentation] Imaging brain aromatase with ^<11>C-labeled cetrozole and its analogs. (2010)
  • Author(s): Takahashi K
  • Organizer: The 16^<th> Takeda Science Foundation Symposium on Bioscience
  • Place of Presentation: 東京
  • Year and Date: 2010-12-01
• [Presentation] Imaging brain aromatase using [^<11>C] cetrozole and its analogs. (2010)
  • Author(s): Takahashi K
  • Organizer: 40^<th> Annual Meeting, Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-15
• [Presentation] ^<11>C-Labeled cetrozole and its analogs : excellent PET probes for aromatase. (2010)
  • Author(s): Takahashi K
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: 京都
  • Year and Date: 2010-09-10
• [Presentation] ^<11>C-Labeled cetrozole and its analogs : an excellent PET probe for aromatase in brain (2010)
  • Author(s): Takahashi K
  • Organizer: Neuro2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Imaging brain aromatase with ^<11>C-labeled cetrozole and its analogs (2010)
  • Author(s): Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Watanabe, Y., Wada, Y., Takashima, T., Katayama, Y., Suzuki, M., Onoe, H., Watanabe, Y
  • Organizer: The 16^<th> Takeda Science Foundation Symposium on Bioscience
  • Place of Presentation: Tokyo, Japan
• [Presentation] Imaging brain aromatase using [^<11>C]cetrozole and its analogs (2010)
  • Author(s): Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Watanabe, Y., Wada, Y., Takashima, T., Katayama, Y., Yamanaka, H., Suzuki, M, Onoe, H., Watanabe, Y
  • Organizer: 40^<th> Annual Meeting, Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
• [Presentation] ^<11>C-Labeled cetrozole and its analogs: an excellent PET probe for aromatase in brain (2010)
  • Author(s): Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Watanabe, Y., Hiramatsu, T., Li, X-L., Wada, Y., Takashima, T., Katayama, Y., Yamanaka, H., Suzuki, M., Onoe, H., Watanabe, Y
  • Organizer: Neuro2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] ^<11>C-Labeled cetrozole and its analogs: excellent PET probes for aromatase (2009)
  • Author(s): Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Watanabe, Y., Wada, Y., Takashima, T., Katayama, Y., Yamanaka, H., Suzuki, M., Onoe. H., Watanabe, Y
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
• [Patent(Industrial Property Rights)] PET用標識化合物 (2010)
  • Inventor(s): 高橋佳代, 他5名
  • Industrial Property Rights Holder: 高橋佳代, 他5名
  • Filing Date: 2010-07-05
  • Overseas