The development of clinical diagnosis for frontotemporal lobar degeneration

• Project/Area Number: 22791157
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: 財団法人東京都医学総合研究所 (2011); Tokyo Metropolitan Organization for Medical Research (2010)
• Principal Investigator: HOSOKAWA Masato 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 (00435116)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 前頭側頭葉変性症 / TDP-43 / ELISA / 脳脊髄液 / 筋萎縮性側索硬化症

Research Abstract

We established the method for quantification of TAR DNA-binding protein of 43 kDa(TDP-43) that was recently identified in frontotemporal lobar degeneration(FTLD) and amyotrophic lateral sclerosis(ALS). Compared with cerebrospinal fluid of ALS and Guillain-Barre syndrome patients, TDP-43 concentration of ALS patients was significantly higher than Guillain-Barre syndrome patients. These results indicated that this method could be useful in the early diagnosis of FTLD.

Research Products

• [Journal Article] Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice (2012)
  • Author(s): Akiyama H, Hosokawa M, Kametani F, Kondo H, Chiba M, Fukushima M, Tabira T
  • Journal Title: Neuropathology Volume: (in press) Issue: 4 Pages: 390-397
  • DOI: 10.1111/j.1440-1789.2011.01274.x
  • Peer Reviewed
• [Journal Article] Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in APP and APP/tau transgenic mice (2011)
  • Author(s): Haruhiko Akiyama, Masato Hosokawa, Fuyuki Kamentani, Hiromi Kondo, Momoko Chiba, Masako Fukushima, Takeshi Tabira
  • Journal Title: Neuropathology Volume: (in press)
  • Peer Reviewed
• [Journal Article] TDP-43分子による新たな認知症群 (2011)
  • Author(s): 新井哲明、細川雅人、長谷川成人、秋山治彦、朝田隆
  • Journal Title: 精神神経学雑誌 Volume: 第113巻第6号 Pages: 574-583
  • NAID: 10029576302
• [Journal Article] 前頭側頭葉変性症の分子病理 (2011)
  • Author(s): 新井哲明、山下万貴子、細川雅人, 他5名
  • Journal Title: Dementia Japan Volume: 25 Pages: 120-127
• [Journal Article] ALS-D-FTLD-MND-FTLD-U (2011)
  • Author(s): 新井哲明、小林禅、細川雅人、長谷川成人、秋山治彦
  • Journal Title: Clinical Neuroscience Volume: 29 Pages: 995-998
• [Journal Article] 認知症臨床に役立つ生物学的精神医学第3回前頭側頭葉変性症と遺伝要因 (2010)
  • Author(s): 細川雅人、新井哲明、秋山治彦、朝田隆
  • Journal Title: 老年精神医学雑誌 Volume: 第21巻第12号 Pages: 1387-1398
• [Journal Article] 認知症の発症にかかわる遺伝子TDP-43 (2010)
  • Author(s): 細川雅人、新井哲明、秋山治彦
  • Journal Title: 老年精神医学雑誌 Volume: 第21巻第5号 Pages: 561-571
• [Journal Article] 認知症の発症に関わる遺伝子 TDP-43 (2010)
  • Author(s): 細川雅人、新井哲明、秋山治彦
  • Journal Title: 老年精神医学雑誌 Volume: 21 Pages: 561-571
• [Journal Article] 前頭側頭葉変性症と遺伝要因 (2010)
  • Author(s): 細川雅人、新井哲明、秋山治彦、朝田隆
  • Journal Title: 老年精神医学雑誌 Volume: 21 Pages: 1387-1398
• [Presentation] Changes in progranulin expression following focal cerebral ischemia associated with microglial activation in mice (2012)
  • Author(s): Furukawa A, Irie K, Akitake Y, Hosokawa M, 他12名
  • Organizer: 第89回日本生理学会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-30
• [Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討 (2012)
  • Author(s): 細川雅人、新井哲明、野中隆, 他5名
  • Organizer: 第132回日本薬学会
  • Place of Presentation: 札幌(北海道大学)
  • Year and Date: 2012-03-29
• [Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice (2011)
  • Author(s): Hosokawa M, Arai T, Nonaka T, 他6名
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington D.C.(USA)
  • Year and Date: 2011-11-13
• [Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討 (2011)
  • Author(s): 細川雅人、新井哲明、野中隆, 他4名
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders (2011)
  • Author(s): Masato Hosokawa, Tetsuaki Arai, Makiko Yamashita, Hiroshi Tsuji, Takashi Nonaka, Masato Hasegawa, Haruhiko Akiyama
  • Organizer: International Conference on Alzheimer's Disease 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-17
• [Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative (2011)
  • Author(s): Hosokawa M, Arai T, Yamashita M, 他4名
  • Organizer: ICAD 2011
  • Place of Presentation: Paris (France)
  • Year and Date: 2011-07-17
• [Presentation] Histopathological analysis of progranulin knockout mice (2011)
  • Author(s): Arai T, Mizukami K, Nishihara M, Hosokawa M, 他6名
  • Organizer: ICAD 2011
  • Place of Presentation: Paris (France)
  • Year and Date: 2011-07-07
• [Remarks]
  • URL: http://www.igakuken.or.jp/