Circadian cycle and Wnt signaling in bipolar disorder
Project/Area Number |
22791161
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
HIDA Akiko 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 室長 (20333354)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | Wntシグナル / 生物時計 / 末梢リズム / 生体組織 |
Research Abstract |
Bipolar disorder is characterized by biological rhythm disturbances as well as mood swings. Emerging evidence indicates that there is a signaling pathway modulating both circadian cycles and mood. The results of this study suggest that Wnt signaling mediates circadian rhythms in cultured fibroblast cells and that fibroblast rhythms predict individual circadian rhythm traits.
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Report
(3 results)
Research Products
(30 results)
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[Presentation] 【Oral】Assessment of individual circadian phenotypes using biopsy samples2011
Author(s)
Hida A, Kitamura S, Watanabe M, Enomoto M, Katayose Y, Aritake S, Higuchi S, Kato M, Moriguchi Y, Ikeda M, Mishima K
Organizer
Neuroscience 2011
Place of Presentation
Washington
Related Report
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[Presentation] 【ポスター発表】末梢組織を利用した生物時計機能評価法2011
Author(s)
肥田昌子,北村真吾,榎本みのり,野崎健太郎,片寄泰子,加藤美恵,渡邊真紀子,有竹清夏,樋口重和,守口善也,池田正明,三島和夫
Organizer
第34回日本神経科学大会-こころの脳科学-
Place of Presentation
神奈川パシフィコ横浜
Related Report
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[Presentation] 【Poster】Evaluation of Individual's Circadian Clock Properties at Physiological and Molecular Levels2011
Author(s)
Hida A, Kitamura S, Watanabe M, Enomoto M, Aritake S, Higuchi S, Nozaki K, Kato M, Moriguchi Y, Mishima K
Organizer
SLEEP 2011, 25th Anniversary Meeting of the Associated Professional Sleep Societies
Place of Presentation
LLC(APSS). Minneapolis, MN, USA
Related Report
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[Presentation] 【ポスター発表】個人の生物時計機能の生理・分子レベルでの評価2011
Author(s)
肥田昌子,北村真吾,渡邊真紀子,榎本みのり,片寄泰子,野崎健太郎,有竹清夏,樋口重和,加藤美恵,守口善也,池田正明,三島和夫
Organizer
第33回日本生物学的精神医学会
Place of Presentation
東京ホテルグランパシフィックLE DAIBA
Related Report
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[Presentation] 【ポスター発表】概日リズム睡眠障害と時計遺伝子多型の関連解析2010
Author(s)
肥田昌子,渡邊真紀子,加藤美恵,北村真吾,榎本みのり,有竹清夏,守口善也,亀井雄一,角谷寛,内山真,井上雄一,海老澤尚,高橋清久,三島和夫
Organizer
日本睡眠学会第35回定期学術集会
Related Report
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[Presentation] 【Poster】Association of circadian gene polymorphisms with sleep characteristics in Japanese population2010
Author(s)
Hida A, Watanabe M, Kitamura S, Kato M, Aritake S, Enomoto M, Moriguchi Y, Mishima K
Organizer
Sleep2010, 24th Annual Meeting of Associated Professional Sleep Societies
Place of Presentation
SanAntonio, TX, USA
Related Report
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