Circadian cycle and Wnt signaling in bipolar disorder

• Project/Area Number: 22791161
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: HIDA Akiko 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 室長 (20333354)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: Wntシグナル / 生物時計 / 末梢リズム / 生体組織

Research Abstract

Bipolar disorder is characterized by biological rhythm disturbances as well as mood swings. Emerging evidence indicates that there is a signaling pathway modulating both circadian cycles and mood. The results of this study suggest that Wnt signaling mediates circadian rhythms in cultured fibroblast cells and that fibroblast rhythms predict individual circadian rhythm traits.

Research Products

• [Journal Article] Pathophysiology and pathogenesis of circadian rhythm sleep disorders (2012)
  • Author(s): Hida A, Kitamura S, Mishima K
  • Journal Title: Journal of Physiological Anthropology Volume: 31 Issue: 1 Pages: 31-31
  • DOI: 10.1186/1880-6805-31-7
  • Peer Reviewed
• [Journal Article] Individual traits and environmental factors influencing an individual's sleep timing : a study of 225 Japanese couples (2012)
  • Author(s): Hida A, Kitamura S, Enomoto M, Nozaki K, Moriguchi Y, Echizenya M, et al
  • Journal Title: Chronobiol Int Volume: 29(2) Issue: 2 Pages: 3220-226
  • DOI: 10.3109/07420528.2011.641045
  • Peer Reviewed
• [Journal Article] Pathophysiology and pathogenesis of circadian rhythm sleep disorders (2012)
  • Author(s): Hida, et al
  • Journal Title: Journal of Physiological Anthropology Volume: 31
  • Peer Reviewed
• [Journal Article] Shift work in nurses : contribution of phenotypes and genotypes to adaptation (2011)
  • Author(s): Gamble KL, Motsinger-Reif AA, Hida A, Borsetti HM, Servick SV, Ciarleglio CM, et al
  • Journal Title: PLoS One Volume: 6(4) Issue: 4 Pages: e18395-e18395
  • DOI: 10.1371/journal.pone.0018395
  • Peer Reviewed
• [Journal Article] 概日リズム睡眠障害の病態生理研究の動向 (2011)
  • Author(s): 肥田昌子、三島和夫
  • Journal Title: 日本生物学的精神医学会誌 Volume: 22 Pages: 165-70
  • NAID: 10029785827
• [Journal Article] Sleep deprivation influences diurnal variation of human time perception with prefrontal activity change : a functional near-infrared spectroscopy study (2010)
  • Author(s): Soshi T, Kuriyama K, Aritake S, Enomoto M, Hida A, Tamura M, et al
  • Journal Title: PLoS One Volume: 5(1) Issue: 1 Pages: e8395-e8395
  • DOI: 10.1371/journal.pone.0008395
  • Peer Reviewed
• [Journal Article] Circadian clock gene Bmal1 is not essential ; functional replacement with its paralog, Bmal2 (2010)
  • Author(s): Shi S, Hida A, McGuinness OP, Wasserman DH, Yamazaki S, Johnson CH.
  • Journal Title: Curr Biol Volume: 20(4) Issue: 4 Pages: 316-21
  • DOI: 10.1016/j.cub.2009.12.034
  • Peer Reviewed
• [Journal Article] Evening preference is related to the incidence of depressive states independent of sleep-wake conditions (2010)
  • Author(s): Kitamura S, Hida A, Watanabe M, Enomoto M, Aritake-Okada S, Moriguchi Y, et al
  • Journal Title: Chronobiol Int Volume: 27(9-10) Issue: 9-10 Pages: 1797-812
  • DOI: 10.3109/07420528.2010.516705
  • Peer Reviewed
• [Journal Article] Sleep-related Problems and Use of Hypnotics in Inpatients of Acute Hospital Wards (2010)
  • Author(s): Enomoto M, Tsutsui T, Higashino S, Otaga M, Higuchi S, Aritake S, et al
  • Journal Title: General Hospital Psychiatry Volume: 32 Issue: 3 Pages: 276-83
  • DOI: 10.1016/j.genhosppsych.2010.01.015
  • Peer Reviewed
• [Journal Article] Diurnal fluctuations in subjective sleep time in humans (2010)
  • Author(s): Aritake-Okada S, Higuchi S, Suzuki H, Kuriyama K, Enomoto M, Soshi T, et al
  • Journal Title: Neurosci Res Volume: 68 Issue: 3 Pages: 225-31
  • DOI: 10.1016/j.neures.2010.07.2040
  • Peer Reviewed
• [Journal Article] Circadian clock gene Bmall is not essential ; functional replacement with its paralog, Bmal2. (2010)
  • Author(s): Shi, et al.
  • Journal Title: Cur Biol Volume: 20 Pages: 316-321
  • Peer Reviewed
• [Journal Article] Evening preference is related to the incidence of depressive states independent of sleep-wake conditions. (2010)
  • Author(s): Kitamura, et al.
  • Journal Title: Chronobiology Int Volume: 27 Pages: 1797-1812
  • Peer Reviewed
• [Journal Article] Diurnal fluctuations in subjective sleep time in humans. (2010)
  • Author(s): Aritake-Okada, et al.
  • Journal Title: Neurosci Res Volume: 68 Pages: 225-231
  • Peer Reviewed
• [Presentation] Genetic and physiological phenotyping of circadian rhythm sleep disorders (2011)
  • Author(s): Hida A.
  • Organizer: Worldsleep2011
  • Place of Presentation: Kyoto International Conference Center, Kyoto(招待講演)
  • Year and Date: 2011-10-19
• [Presentation] 【Oral】Assessment of individual circadian phenotypes using biopsy samples (2011)
  • Author(s): Hida A, Kitamura S, Watanabe M, Enomoto M, Katayose Y, Aritake S, Higuchi S, Kato M, Moriguchi Y, Ikeda M, Mishima K
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington
• [Presentation] 【口頭・ポスター発表】生体組織を利用した生物時計機能評価-概日リズム睡眠障害者への応用- (2011)
  • Author(s): 肥田昌子,大澤要介,北村真吾,榎本みのり,片寄泰子,野崎健太郎,守口善也,亀井雄一,池田正明,三島和夫
  • Organizer: 第18回日本時間生物学会学術大会
  • Place of Presentation: 愛知名古屋大学
• [Presentation] 【Plenary Symposia】Genetic and physiological phenotyping of circadian rhythm sleep disorders (2011)
  • Author(s): Hida A
  • Organizer: Worldsleep2011
  • Place of Presentation: Kyoto Kyoto International Conference Center
• [Presentation] 【ポスター発表】末梢組織を利用した生物時計機能評価法 (2011)
  • Author(s): 肥田昌子,北村真吾,榎本みのり,野崎健太郎,片寄泰子,加藤美恵,渡邊真紀子,有竹清夏,樋口重和,守口善也,池田正明,三島和夫
  • Organizer: 第34回日本神経科学大会-こころの脳科学-
  • Place of Presentation: 神奈川パシフィコ横浜
• [Presentation] 【Poster】Evaluation of Individual's Circadian Clock Properties at Physiological and Molecular Levels (2011)
  • Author(s): Hida A, Kitamura S, Watanabe M, Enomoto M, Aritake S, Higuchi S, Nozaki K, Kato M, Moriguchi Y, Mishima K
  • Organizer: SLEEP 2011, 25th Anniversary Meeting of the Associated Professional Sleep Societies
  • Place of Presentation: LLC(APSS). Minneapolis, MN, USA
• [Presentation] 【ポスター発表】個人の生物時計機能の生理・分子レベルでの評価 (2011)
  • Author(s): 肥田昌子,北村真吾,渡邊真紀子,榎本みのり,片寄泰子,野崎健太郎,有竹清夏,樋口重和,加藤美恵,守口善也,池田正明,三島和夫
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京ホテルグランパシフィックLE DAIBA
• [Presentation] 【シンポジウム】概日リズム睡眠障害の診断法の確立に向けて (2011)
  • Author(s): 肥田昌子,三島和夫
  • Organizer: 第17回日本時間生物学会学術大会
  • Place of Presentation: 東京
• [Presentation] 【Symposium】Evaluation of individual's circadian rhythms at physiological and molecular levels (2010)
  • Author(s): Hida A, Mishima K
  • Organizer: Neuro2010
  • Place of Presentation: Kobe, Japan
• [Presentation] 【ポスター発表】概日リズム睡眠障害と時計遺伝子多型の関連解析 (2010)
  • Author(s): 肥田昌子,渡邊真紀子,加藤美恵,北村真吾,榎本みのり,有竹清夏,守口善也,亀井雄一,角谷寛,内山真,井上雄一,海老澤尚,高橋清久,三島和夫
  • Organizer: 日本睡眠学会第35回定期学術集会
• [Presentation] 【Poster】Association of circadian gene polymorphisms with sleep characteristics in Japanese population (2010)
  • Author(s): Hida A, Watanabe M, Kitamura S, Kato M, Aritake S, Enomoto M, Moriguchi Y, Mishima K
  • Organizer: Sleep2010, 24th Annual Meeting of Associated Professional Sleep Societies
  • Place of Presentation: SanAntonio, TX, USA
• [Presentation] 概日リズム睡眠障害の診断法の確立に向けて (2010)
  • Author(s): 肥田昌子、三島和夫
  • Organizer: 第17回日本時間生物学会学術大会
  • Place of Presentation: 東京、早稲田大学国際会議場
• [Book] 気分障害と生物時計システム-リズム異常をもたらす生物時計機能障害評価法,医学のあゆみ (2011)
  • Author(s): 肥田昌子,三島和夫
• [Book] 概日リズム睡眠障害の病態生理研究の動向,日本生物学的精神医学会誌 (2011)
  • Author(s): 肥田昌子,三島和夫
• [Book] 認知症患者の概日リズムの乱れに対するメラトニン治療の効果,せん妄に対しても効果はあるか?. Cognition and Dementia (2011)
  • Author(s): 肥田昌子,三島和夫
• [Book] 概日リズム睡眠障害の病態生理,睡眠医療 (2011)
  • Author(s): 肥田昌子
• [Remarks]
  • URL: http://www.ncnp.go.jp/nimh/division/seiri.html