Possibility to the treatment for radiation-induced skin damages using monocytes and acrophages.

• Project/Area Number: 22791164
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Tottori University
• Principal Investigator: TAKAHASHI Kenji 鳥取大学, 農学部, 准教授 (00400143)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 放射線治療生物学 / 炎症 / 再生 / 疼痛 / 炎症細胞 / 痛覚神経

Research Abstract

In this research, to study a skin pain, one of radiation-induced skin damages, effects of DNA damaging agent, paclitaxel on transient potential ankyrin 1(TRPA1), one of polymodal receptors using cell line RIN-14B expressing TRPA1.

Research Products

• [Journal Article] Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal tis functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates (2012)
  • Author(s): Ohkita M, Saito S, Imagawa T, Takahashi K, Tominaga M, Ohta T
  • Journal Title: Journal of Biological Chemistry Volume: 287(4) Pages: 2388-2397
  • Peer Reviewed
• [Journal Article] Molecular Cloning and Functional Characterization of Xenopus tropicalis Frog Transient Receptor Potential Vanilloid 1 Reveal Its Functional Evolution for Heat, Acid, and Capsaicin Sensitivities in Terrestrial (2012)
  • Author(s): Ohkita M, Saito S, Imagawa T, Takahashi K, Tominaga M, Ohta T
  • Journal Title: Vertebrates. J Biol Chem Volume: 287(4) Issue: 4 Pages: 2388-97
  • DOI: 10.1074/jbc.m111.305698
  • Peer Reviewed
• [Journal Article] Terminal maturation of megakaryocytes and platelet production by hematopoietic stem cells irradiated with heavy-ion beams (2011)
  • Author(s): Monzen S, Takahashi K, Yoshino H, Kasai-Eguchi K, Kashiwakura I
  • Journal Title: Radiation Research Volume: 176(1) Pages: 8-16
  • Peer Reviewed
• [Journal Article] (-)-Epigallocatechin-3-O-gallate induces nonapoptotic cell death in leukemia cells independent of the 67 kDa laminin receptor (2011)
  • Author(s): Hazawa M, Takahashi K, Sugata S, Kashiwakura I
  • Journal Title: Journal of Natural Products Volume: 74(4) Pages: 695-700
  • Peer Reviewed
• [Journal Article] Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells (2010)
  • Author(s): Kato K, Takahashi K, Monzen S, Yamamoto H, Maruyama A, Itoh K, Kashiwakura I
  • Journal Title: Radiation Research Volume: 174(2) Pages: 177-184
  • Peer Reviewed
• [Journal Article] Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells. (2010)
  • Author(s): Kato, et al.
  • Journal Title: Radiation Research Volume: 174 Pages: 177-184
  • Peer Reviewed
• [Presentation] 酸性条件下における2-aminoethoxydiphenyl borateによるPC12細胞の細胞死誘発作用 (2011)
  • Author(s): 高橋賢次
  • Organizer: 第64回日本薬理学会西南部会
  • Place of Presentation: KKRホテル博多(福岡)
  • Year and Date: 2011-11-19
• [Presentation] 酸性条件下における2-aminoethoxydiphenyl borateによるPC12細胞の細胞死誘発作用 (2011)
  • Author(s): 高橋賢次, 太田利男
  • Organizer: 第64回日本薬理学会西南部会
  • Place of Presentation: 福岡市