Optimization and standardization of longitudinal brain image analysis for dementia

Research Project

Project/Area Number	22791165
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	KANETA Tomohiro 東北大学, 病院, 助教 (50323019)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	Alzheimer病 / 脳画像解析 / 縦断的評価 / Positron Emission Tomography
Research Abstract	The aim of this study was to optimize and standardize the analysis method for the longitudinal brain image evaluation for dementia. Neurostat program was used for 3D-SSP analyses. As the index for the evaluation, A)posterior cingulate cortex (PCC), and B)PCC+ parietal and tempotal lobes showed relatively small sample size for the detection of the changes over time. However, these values seem to be large for the clinical trials of the new drugs for Alzheimer's disease. Further investigation is required.

Report

(3 results)