Fundamental research of X-ray and carbon ion beam radiation sensitivity for the treatment of hypoxic tumor cells and investigation of its molecular biological mechanism.
Project/Area Number |
22791171
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Radiation science
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Research Institution | Gunma University |
Principal Investigator |
SAITOH Jun-ichi 群馬大学, 大学院・医学系研究科, 講師 (70572816)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 放射線感受性 / 低酸素 / HIF-1α / 一酸化窒素 |
Research Abstract |
Changes of the expression of hypoxic marker HIF-1αand radiation sensitivity under hypoxic conditions with HIF-1αinhibitor were investigated. Hypoxic tumor cells were exposed to radiation with or without HIF-1αinhibitor YC-1 or nitric oxide synthase inhibitor L-NMMA. The expressions of HIF-1αunder hypoxic conditions (>0.1mmHg) were inhibited with YC-1 or L-NMMA, but radiosensitizing effects with these drugs under acute hypoxic conditions were not observed.
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Report
(3 results)
Research Products
(6 results)