| Project/Area Number |
22791179
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
KITAMURA Yoji 金沢大学, 学際科学実験センター, 准教授 (10368483)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射性医薬品 / ポルフィリン / 腫瘍 / 錯体 |
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| Research Abstract |
In this study, a new radiometal-octabromoporphyrines was developed and the possibililty of application for a new nuclear medicine diagnosis and radioisotope therapy agent was examined. As a result, it was found that Octabromotetrakis(4-carboxyphenyl) porphine(OBTCPP) could be radiolabelled by 111In, a radio nuclear for diagnosis, in short times. It was also found that, in tumor bearing mice which transplanted colon26 tumor cell and B16/BL6 tumor cell, 111In-OBTCPP was accumulated in both tumors at about 7% dose/g.
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