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Inhibition of Fibrosis and Inflammation by Triple Therapy with Pirfenidone, Edaravone, and Erythropoietin in Rabbits with Drug-Induced Lung Injury : Computed Tomography-Pathological Correlation

Research Project

Project/Area Number 22791185
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionShiga University of Medical Science

Principal Investigator

WATANABE Shobu  滋賀医科大学, 医学部, 医員 (60570364)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords薬剤性肺障害 / ブレオマイシン / ピルフェニドロン / エダラボン / エリスロポイエチン / 薬剤性肺傷害 / アシアロエリスロポエチン / 医療・福祉 / 放射線 / 病理学
Research Abstract

We divided drug-induced lung injury rabbits into 3groups ; the control group(G1), pirfenidone group(G2), and a three-drug combination group(G3)(pirfenidone, edaravone, and erythropoietin). CT on day 28, G3 tended to exhibit a smaller area with abnormal opacity compared with G1(p=0. 071). In microscopic specimens, the average fibrosis score showed a significant difference between G1 and G3(p<0. 05). Moreover, the average fibrosis score tended to be smaller in G3 than in G2(p<0. 1).
From the above, administration of pirfenidone alone suppressed the advancement of drug-induced lung injury, but the three-drug combination prevented further progression.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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