Development of high sensitive MRI contrast agent encapsulating CEST agent into apoferritin cavity

Research Project

Project/Area Number	22791187
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	Kyoto University (2011) Shimadzu Corporation (2010)
Principal Investigator	MAKINO Akira 京都大学, 大学院・薬学研究科, 特定助教 (00566226)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	核磁気共鳴画像 / CEST / アポフェリチン
Research Abstract	Lanthanoid complexes having various electric charges were newly designed and synthesized as new chemical exchange and saturation transfer(CEST) agents. The complexes were encapsulated into apoferritin cavity, and thier character as CEST type MRI contrast agent was evaluated in vitro. Further, surface of apoferritin is modified with hydrophilic polymers to extend its blood circulation behavior, and I succeeded to deliver the dextran-coated apoferritin to transplanted tumor region utilizing enhanced permeation and retention(EPR) effect. Performance of the apoferritin MRI contrast agent encapsulating CEST agent in vivo was examined using tumor-transplanted mouse.

Report

(3 results)