• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of high sensitive MRI contrast agent encapsulating CEST agent into apoferritin cavity

Research Project

Project/Area Number 22791187
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyoto University (2011)
Shimadzu Corporation (2010)

Principal Investigator

MAKINO Akira  京都大学, 大学院・薬学研究科, 特定助教 (00566226)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords核磁気共鳴画像 / CEST / アポフェリチン
Research Abstract

Lanthanoid complexes having various electric charges were newly designed and synthesized as new chemical exchange and saturation transfer(CEST) agents. The complexes were encapsulated into apoferritin cavity, and thier character as CEST type MRI contrast agent was evaluated in vitro. Further, surface of apoferritin is modified with hydrophilic polymers to extend its blood circulation behavior, and I succeeded to deliver the dextran-coated apoferritin to transplanted tumor region utilizing enhanced permeation and retention(EPR) effect. Performance of the apoferritin MRI contrast agent encapsulating CEST agent in vivo was examined using tumor-transplanted mouse.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent2011

    • Author(s)
      Akira Makino, Hiroshi Harada, Tomohisa Okada, Hiroyuki Kimura, Hiroo Amano, Hideo Saji, Masahiro Hiraoka, Shunsaku Kimura
    • Journal Title

      Nanomedicine, Nanotech. Biol. Med

      Volume: 7 Issue: 5 Pages: 638-646

    • DOI

      10.1016/j.nano.2011.01.015

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Peptide-and Protein-based Molecular Assemblies and Its Utilization as Nanocarriers for Tumor Imaging2011

    • Author(s)
      Akira Makino, Shunsaku Kimura
    • Journal Title

      React. Funct. Polym

      Volume: 71 Pages: 271-279

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Peptide- and Protein-based Molecular Assemblies and Its Utilization as Nanocarriers for Tumor Imaging2011

    • Author(s)
      牧野顕
    • Journal Title

      Reactive and Functional Polymer

      Volume: 71 Pages: 271-279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi