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New treatment for cancer metastasis targeting tumor hypoxia

Research Project

Project/Area Number 22791190
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

ITASAKA Satoshi  京都大学, 医学研究科, 助教 (90378654)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords放射線治療生物学 / 転移 / 放射線治療 / 低酸素 / イメージング / 肺転移モデル
Research Abstract

We have developed the mouse lung metastasis model that allows us to monitor intra-tumor hypoxia during the formation of lung metastasis. We found that progress of lung metastasis was accelerated by transient up-regulation of HIF-1 activity that was dependent upon reactive oxygen species(ROS). This lead to a cellular metabolic reprogramming, that is a change from mitochondrial oxidative phosphorylation to lactic acid fermentation. The use of HIF-1 inhibitor significantly decreased the formation of lung metastasis.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: The Japanese Radiation Oncology Study Group (JROSG) survey.2012

    • Author(s)
      Nishimura Y
    • Journal Title

      Int J Clin Oncol

      Volume: 17 Issue: 1 Pages: 48-54

    • DOI

      10.1007/s10147-011-0254-y

    • NAID

      10030548388

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed initial radioactive iodine therapy resulted in poor survival in patients with metastatic differentiated thyroid carcinomaa retrospective statistical analysis of 198 cases2011

    • Author(s)
      Higashi T, Nishii R, Yamada S, Nakamoto Y, Ishizu K, Kawase S, Togashi K, Itasaka S, Hiraoka M, Misaki T, Konishi J.
    • Journal Title

      The Journal of Nuclear Medicine

      Volume: 52(5) Issue: 5 Pages: 683-689

    • DOI

      10.2967/jnumed.110.081059

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic a ctivity of tumor cells2010

    • Author(s)
      Zhao T, Harada H, Teramura Y, Tanaka SItasaka S, Morinibu A, Shinomiya K, Zhu Y, Hanaoka H, Iwata H, Saji H, Hiraoka M
    • Journal Title

      Journal of Controlled Release

      Volume: 144 Issue: 1 Pages: 109-114

    • DOI

      10.1016/j.jconrel.2010.01.023

    • Related Report
      2011 Final Research Report
  • [Journal Article] A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells2010

    • Author(s)
      Zhao T, Harada H, Teramura Y, Tanaka S, Itasaka S, Morinibu A, Shinomiya K, Zhu Y, Hanaoka H, Iwata H, Saji H, Hiraoka M
    • Journal Title

      Journal of Controlled Release

      Volume: 144 Pages: 109-114

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Influe nce of glucose-deprivati on cell cycle status and cellular radio resistance under hypoxic conditions2011

    • Author(s)
      Zhao T, Zhu Y, Itasaka S, Ogura M, Y oshimura M, Harada H, Hiraoka M.
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2011-02-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Influence of glucose-deprivation on cell cycle status and cellular radioresistance under hypoxic conditions2011

    • Author(s)
      Zhao T, Zhu Y, Itasaka S, Ogura M, Yoshimura M, Harada H, Hiraoka M
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2011-02-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optical imaging probe for matrix metalloproteinases activity in malignant tumors2010

    • Author(s)
      Zhao T, Harada H, Teramura Y, Tanaka S, Itasaka S, Morinibu A, Shinomiya K, Zhu Y, Hanaoka H, Iwata H, SAji H, Hiraoka M
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      京都
    • Year and Date
      2010-09-09
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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