| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
We aimed at a development of the nanocarrier who is able to diagnose carcinoma. By using the Lactsome labeled by ICG, or 18F, or 123I, this study was performed to improve depiction of carcinoma. We searched the methods how to avoid an Accelerated Blood Clearance(ABC) phenomenon, which peculiarly appeared when the 20-100nm nanocarrier was administered at the second time. As a result, we were able to compose Lactsome labeled by ICG, or 18F, or 123I etc. And we comfirmed small animal PET imaging condition, and performed biodistribution. Besides, we found out some methods to let an ABC phenomenon diminish. However, we were not able to let an ABC phenomenon completely disappear.
|
