Optimization of loading superabsorbent polymer microspheres with anticancer drugs for use in chemoembolization of liver tumors unresponsive to standard therapy
| Project/Area Number |
22791195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Noboru 大阪大学, 医学(系)研究科(研究院), 助教 (00506488)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 動脈塞栓術 / 化学塞栓療法 / 薬剤溶出性塞栓物質 / 高吸水性ポリマー / 肝腫瘍 / 抗癌剤 / エピルビシン / イリノテカン / 転移性肝腫瘍 / CPT-11 / 肝癌 / アンスラサイクリン系 |
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| Research Abstract |
The purpose of this study was to optimize the preparation for loading superabsorbent polymer (SAP) microspheres with anticancer drugs as an efficient drug delivery system for use in chemoembolization of liver tumors unresponsive to standard therapy in clinical practice. Iodinated contrast medium, nonionic isosmotic iodinated contrast medium and undiluted irinotecan solutions for intravenous drip infusion were most suitable for solvent in loading SAP microspheres with cisplatin, epirubicin and irinotecan, respectively. This result of in vivo study in a rabbit model with transplanted liver VX2 tumors suggested that chemoembolization with anticancer drug-loaded SAP microspheres was more effective in suppressing the tumor growth.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] In vivo evaluation of cisplatin-loaded superabsorbent polymer microspheres for use in chemoembolization of VX2 liver tumors2012
Author(s)
Maeda N, Osuga K, Shimazu K, Morii E, Mikami K, Hori S, Nakazawa T, Higashihara H, Tomoda K, Nakamura H, Tomiyama N
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Journal Title
J Vasc Interv Radiol
Volume: 23(3):397-404
Related Report
Peer Reviewed
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