• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Optimization of loading superabsorbent polymer microspheres with anticancer drugs for use in chemoembolization of liver tumors unresponsive to standard therapy

Research Project

Project/Area Number 22791195
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

MAEDA Noboru  大阪大学, 医学(系)研究科(研究院), 助教 (00506488)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords動脈塞栓術 / 化学塞栓療法 / 薬剤溶出性塞栓物質 / 高吸水性ポリマー / 肝腫瘍 / 抗癌剤 / エピルビシン / イリノテカン / 転移性肝腫瘍 / CPT-11 / 肝癌 / アンスラサイクリン系
Research Abstract

The purpose of this study was to optimize the preparation for loading superabsorbent polymer (SAP) microspheres with anticancer drugs as an efficient drug delivery system for use in chemoembolization of liver tumors unresponsive to standard therapy in clinical practice. Iodinated contrast medium, nonionic isosmotic iodinated contrast medium and undiluted irinotecan solutions for intravenous drip infusion were most suitable for solvent in loading SAP microspheres with cisplatin, epirubicin and irinotecan, respectively. This result of in vivo study in a rabbit model with transplanted liver VX2 tumors suggested that chemoembolization with anticancer drug-loaded SAP microspheres was more effective in suppressing the tumor growth.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results)

  • [Journal Article] In vivo evaluation of cisplatin-loaded superabsorbent polymer microspheres for use in chemoembolization of VX2 liver tumors2012

    • Author(s)
      Maeda N, Osuga K, Shimazu K, Morii E, Mikami K, Hori S, Nakazawa T, Higashihara H, Tomoda K, Nakamura H, Tomiyama N
    • Journal Title

      J Vasc Interv Radiol

      Volume: 23(3):397-404

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo evaluation of cisplatin-loaded superabsorbent polymer microspheres for use in chemoembolization of VX2 liver tumors2012

    • Author(s)
      Noboru Maeda, et al
    • Journal Title

      Joumal of Vascular and Interventional Radiology

      Volume: Vol.23 Pages: 397-404

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro characterization of cisplatin-loaded superabsorbent polymer microspheres designed for chemoembolization2010

    • Author(s)
      Maeda N, Osuga K, Mikami K, Higashihara H, Mikami K, Tomoda K, Hori S, Nakazawa T, Nakamura H
    • Journal Title

      J Vasc Interv Radiol

      Volume: 21(6):877-81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro characterization of cisplatin-loaded superabsorbent polymer microspheres designed for chemoembolization2010

    • Author(s)
      Noboru Maeda, et al.
    • Journal Title

      Journal of Vascular and Interventional Radiology

      Volume: Vol.21 Pages: 877-881

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] イリノテカンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討2013

    • Author(s)
      岸本健太郎、前田登、日高国幸、大須賀慶悟、田中会秀、中村純寿、小野祐介、中澤哲郎、東原大樹、富山憲幸
    • Organizer
      第42回日本IVR学会総会
    • Place of Presentation
      軽井沢
    • Year and Date
      2013-05-16
    • Related Report
      2012 Final Research Report
  • [Presentation] イリノテカンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討2013

    • Author(s)
      岸本健太郎、前田登、大須賀慶悟、田中会秀、中村純寿、小野祐介、中澤哲郎、東原大樹、富山憲幸
    • Organizer
      第72回日本医学放射線学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] イリノテカンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討2013

    • Author(s)
      岸本健太郎、前田登、他
    • Organizer
      第72回日本医学放射線学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] イリノテカンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討2013

    • Author(s)
      岸本健太郎、前田登、他
    • Organizer
      第42回日本IVR学会総会
    • Place of Presentation
      軽井沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vitro characterization of epirubicin-loaded Hepaspheres (superabsorbent polymer microspheres) designed for chemoembolization2012

    • Author(s)
      Maeda N, Osuga K, Tanaka K, Kishimoto K, Nakamura M, Nakazawa T, Higashihara H, Tomoda K, Tomiyama N.
    • Organizer
      American Roentgen Ray Society (ARRS) 2012 Annual Meeting
    • Place of Presentation
      Vancouver,Canada
    • Year and Date
      2012-04-29
    • Related Report
      2012 Final Research Report
  • [Presentation] In vitro characterization of epirubicin-loaded Hepaspheres (superabsorbent polymer microspheres) designed for chemoembolization.2012

    • Author(s)
      Maeda N et al.
    • Organizer
      American Roentgen Ray Society (ARRS) 2012 Annual Meeting
    • Place of Presentation
      Vancouver
    • Related Report
      2012 Annual Research Report
  • [Presentation] エピルビシンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討2011

    • Author(s)
      前田登、大須賀慶悟、東原大樹、中澤哲郎、友田要、富山憲幸
    • Organizer
      第40回日本IVR学会総会
    • Place of Presentation
      青森
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] エピルビシンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討2011

    • Author(s)
      前田登、大須賀慶悟、東原大樹、中澤哲郎、友田要、富山憲幸
    • Organizer
      第70回日本医学放射線学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] エピルビシンを用いた薬剤溶出性高吸水性ポリマー(Hepasphere)のin vitroでの検討2011

    • Author(s)
      前田登, 他
    • Organizer
      第70回日本医学放射線学会総会・学術集会
    • Place of Presentation
      (web開催)
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi