A fundamental study for particle radiotherapy with concurrent gene therapy using Ad-p53
| Project/Area Number |
22791198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 放射線治療 / 放射線抵抗性 / 放射線増感作用 / Ad-p53 / X線 / 粒子線 |
|---|
| Research Abstract |
TiOxNP induced ROS generation with X-ray irradiation. Tumor growth inhibitions were significantly greater in mice treated with the combination compared with those treated with X-ray alone. The combination MGDG and X-ray irradiation significantly increased the proportion of apoptotic cells in vitro. In vivo studies, tumor growth inhibitions were significantly greater in mice treated with the combination compared with those treated with X-ray alone.
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Report
(4 results)
Research Products
(134 results)
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[Journal Article] Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index2012
Author(s)
Uehara K, Sasayama T, Miyawaki D, Nishimura H, Yoshida K, Okamoto Y, Mukumoto N, Akasaka H, Nishihara M, Fujii O, Soejima T, Sugimura K, Kohmura E, Sasaki R
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Journal Title
Radiat Oncol
Volume: 26(7)
Pages: 104-104
Related Report
Peer Reviewed
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[Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy2012
Author(s)
Hashimoto N, Sasaki R, Nishimura H, Yoshida K, Miyawaki D, Nakayama M, Uehara K, Okamoto Y, Ejima Y, Azumi A, Matsui T, Sugimura K
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82(4)
Pages: 1509-14
Related Report
Peer Reviewed
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[Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus.2011
Author(s)
Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Niwa Y, Mima M, Fujii O, Sasaki R, Yamada I, Hori Y, Hishikawa Y, Abe M, Ku Y, Murakami M
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Journal Title
Jgastroenterol
Volume: 46(7)
Pages: 913-20
NAID
Related Report
Peer Reviewed
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