Molecular-targeted therapy of venous thromboembolism

• Project/Area Number: 22791206
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Miyazaki
• Principal Investigator: FURUKOUJI Eiji 宮崎大学, 医学部, 助教 (00423723)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 深部静脈血栓症 / 遺伝子導入 / 静脈 / Clec-2 / CLEC-2

Research Abstract

Platelet activation receptor CLEC-2 binds to podoplanin, thereby leading to platelet activation and thrombus formation. The present study examines whether local gene transfer suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to venous wall competitively. As a result, although further studies are needed, the possibility of persistent expression of target protein and antithrombotic effect were suggested in a rat model of venous thrombosis.