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Development of the next generation MR Elastography actuator

Research Project

Project/Area Number 22791211
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionTokyo Metropolitan University

Principal Investigator

NUMANO Tomokazu  首都大学東京, 人間健康科学研究科, 准教授 (10399511)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords核磁気共鳴画像(MRI) / MR Elastography / MRI / Actuator / shear wave / Magnetic Resonance Imaging : MRI / Ball-vibrator / Motion Sensitizing Gradient : MSG / MR Phase image / Elastogram / Synchronization / Wave image / Magnetic Resonance Imagin : MRI
Research Abstract

The purpose of this study was to develop a new technique for a powerful compact MR elastography (MRE)actuator based on a pneumatic ball-vibrator. This is a compact actuator that generates powerful centrifugal force vibrations via high speed revolutions of an internal ball using compressed air. This equipment is easy to handle due to its simple principles and structure. Vibration frequency and centrifugal force are freely adjustable via air pressure changes (air flow volume), and replacement of the internal ball. In order to achieve MRI compatibility, all parts were constructed from non-ferromagnetic materials. Vibration amplitudes (displacements) were measured optically by a laser displacement sensor. From a bench test of displacement, even though the vibration frequency increased, the amount of displacement did not decrease. An essential step in MRE is the generation of mechanical waves within tissue via an actuator, and MRE sequences are synchronized to several phase offsets of vibration. In this system, the phase offset was detected by a four-channel optical-fiber sensor, and it was used as an MRI trigger signal. In an agarose gel phantom experiment, this actuator was used to make an MR elastogram. This study shows that the use of a ball actuator for MRE is feasible.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (57 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 5 results) Presentation (45 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] Magnetic Resonance Elastography using an air ball-actuator2013

    • Author(s)
      Numano T, Kawabata Y, Mizuhara K, Washio T, Nitta N, Homma K
    • Journal Title

      Magnetic Resonance Imaging

    • NAID

      120006627249

    • Related Report
      2012 Final Research Report
  • [Journal Article] Magnetic resonance elastography using an air ball-actuator2013

    • Author(s)
      Numano T, Kawabata Y, Mizuhara K, Washio T, Nitta N, Homma K
    • Journal Title

      Magnetic Resonance Imaging

      Volume: accepted Issue: 6 Pages: 393-946

    • DOI

      10.1016/j.mri.2013.02.001

    • NAID

      120006627249

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of diffusion-weighted stimulated echo pulse sequence in human skeletal muscle2013

    • Author(s)
      Hata J, Yagi K, Hikishima K, Numano T, Goto M, Yano K
    • Journal Title

      Radiol Phys Technol.

      Volume: Jan;6(1) Issue: 1 Pages: 92-7

    • DOI

      10.1007/s12194-012-0174-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling shear modulus distribution in magnetic resonance elastography with piecewise constant level sets2012

    • Author(s)
      Li BN, Chui CK, Ong SH, Numano T, Washio T, Homma K, Chang S, Venkatesh S, Kobayashi E
    • Journal Title

      Magnetic Resonance Imaging

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] MR Elastographyを用いた筋収縮による硬度変化の計測2012

    • Author(s)
      畑純一, 沼野智一, 水原和行, 鷲尾利克, 高本孝一, 西条寿夫, 本間一弘, 八木一夫
    • Journal Title

      日本磁気共鳴医学会雑誌

      Volume: 32

    • NAID

      10030284994

    • Related Report
      2012 Final Research Report
  • [Journal Article] Abnormal brain MRI signal in 18q-syndrome not due to dysmyelination2012

    • Author(s)
      Tanaka R et al.
    • Journal Title

      Brain Dev

      Volume: 34 Issue: 3 Pages: 234-237

    • DOI

      10.1016/j.braindev.2011.05.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between apparent diffusion coefficient and viscoelasticity of articular cartilage in a porcine model2012

    • Author(s)
      Aoki T, Watanabe A, Nitta N, Numano T, Fukushi M, Niitsu M
    • Journal Title

      Skeletal Radiol.

      Volume: Sep;41(9) Issue: 9 Pages: 1087-92

    • DOI

      10.1007/s00256-011-1340-y

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRエラストグラフィがもたらす情報-筋の硬さ評価を中心に2012

    • Author(s)
      沼野智一
    • Journal Title

      INNERVISION

      Volume: 27 Pages: 24-27

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Evaluation of negative fixed-charge density in tissue-engineered cartilage by quantitative MRI and relationship with biomechanical properties.2010

    • Author(s)
      Miyata S, Homma K, Numano, T, Tateishi T, Ushida T
    • Journal Title

      J Biomech Eng.

      Volume: 132 Pages: 710-14

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Simple MR Elastography: A Gradient-Echo type Multiecho MR Sequence2013

    • Author(s)
      T Numano, J Hata, K Mizuhara, K Takamoto, T Washio, H Nishijo, K Yagi, K Homma
    • Organizer
      The International Society for Magnetic Resonance in Medicine 21th Annual Meeting & Exhibition
    • Place of Presentation
      Salt Lake City, Utah, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Magnetic Resonance Elastography by using a Multi-echo MRI sequence2013

    • Author(s)
      T Numano, J Hata, K Mizuhara, K Takamoto, T Washio, H Nishijyo
    • Organizer
      第69回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 臨床用MRI 装置による簡易的MR Elastographyの生体応用2012

    • Author(s)
      沼野智一, 畑純一, 水原和行, 高本幸一, 西条寿夫, 加藤洋, 本間一弘
    • Organizer
      第11回 コ・メディカル形態機能学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 拡散強調スパイラルシーケンスの開発と生体応用2012

    • Author(s)
      沼野智一, 兵藤行志, 新田尚隆, 岩崎 信明, 本間一弘
    • Organizer
      第24回臨床MR脳機能研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Measurement of Thigh Muscle Stiffness by Using Simple Method of Magnetic Resonance Elastography2012

    • Author(s)
      T. Numano, J.Hata, K. Mizuhara, K. Takamoto, H. Katagiri, T. Washio, H. Nishijyou, K. Yagi, K. Homma
    • Organizer
      EPOS of the European Congress of Radiology (ECR 2012)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] マルチエコーシーケンスによるMR Elastography2012

    • Author(s)
      沼野智一, 畑純一, 水原和行, 高本幸一, 鷲尾利克, 西条寿夫, 八木一夫, 本間一弘
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] MR Elastographyによる筋組織異方構造の解析2012

    • Author(s)
      畑純一,沼野智一,水原和行,高本孝一,鷲尾利克,西条寿夫,本間一弘,八木一夫,矢野敬一
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 強制加振部固定方法がMR Elastographyに与える影響2012

    • Author(s)
      沼野智一, 畑純一, 水原和行, 高本孝一, 片桐秀樹, 鷲尾利克, 本間一弘
    • Organizer
      第68回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 拡散強調スパイラルシーケンスの開発2012

    • Author(s)
      沼野智一, 兵藤行志, 新田尚隆, 岩崎 信明, 本間一弘
    • Organizer
      第68回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 臨床用MRI装置による簡易的MR Elastographyの生体応用2012

    • Author(s)
      沼野智一, 畑純一, 水原和行, 高本孝一, 西条寿夫, 加藤洋, 本間一弘
    • Organizer
      第 11 回 コ・メディカル形態機能学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Measurement of Thigh Muscle Stiffness by Using Simple Method of Magnetic Resonance Elastography2012

    • Author(s)
      T.Numano. J.Hata, K.Mizuhara, K.Takamoto, H.Katagiri, T.Washio, H.Nishijyou, K.Yagi, K.Homma
    • Organizer
      EPOS of the European Congress of Radiology (ECR 2012)
    • Place of Presentation
      ウイーン
    • Related Report
      2011 Annual Research Report
  • [Presentation] MR Elastographyを用いた筋収縮による硬度変化の計測2011

    • Author(s)
      畑純一, 沼野智一, 水原和行, 鷲尾利克, 高本孝一, 片桐秀樹, 西条寿夫
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      北九州
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 加振動装置固定の適否がMR Elastographyに与える影響2011

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行, 高本孝一, 片桐秀樹, 西条寿夫
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      北九州
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体臓器を対象とした外部加振法の提案2011

    • Author(s)
      鷲尾利克, 水原和行, 沼野智一, 本間一弘
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      北九州
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Magnetic Resonance Elastography with an Air Ball-Vibrator2011

    • Author(s)
      T.Numano, Y.Kawabata, T.Washio, K.Mizuhara, N.Nitta, K.Homma
    • Organizer
      International Society for Magnetic Resonance in Medicine ISMRM 19th Annual Meeting & Exhibition
    • Place of Presentation
      モントリオール
    • Year and Date
      2011-05-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 簡易的MR Elastographyパルスシーケンスによる弾性率画像表示2011

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行, 高本孝一, 八木一夫, 西条寿夫
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 次世代型MRI対応加振動装置によるMR Elastography2011

    • Author(s)
      沼野智一, 川畑義彦, 鷲尾利克, 水原和行, 新田尚隆, 本間一弘
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 次世代型MRI対応加振動装置の開発と性能評価2011

    • Author(s)
      沼野智一, 川畑義彦
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 拡散強調MRI-Diffusion Weighted Imagingの基礎と原理-2011

    • Author(s)
      沼野智一
    • Organizer
      都立病院放射線技師会勉強会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-02-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] はじめてのMR Eiastography-パルスシーケンスと撮像法-2011

    • Author(s)
      沼野智一
    • Organizer
      肝線維症診断の夕べ~MR Elastographyを語ろう~
    • Place of Presentation
      岐阜市(招待講演)
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 1484Magnetic Resonance Elastography with an Air Ball-Vibrator2011

    • Author(s)
      T. Numano, Y. Kawabata, T. Washio, K. Mizuhara, N. Nitta, K. Homma
    • Organizer
      International Society for Magnetic Resonance in Medicine ISMRM 19th Annual Meeting & Exhibition
    • Place of Presentation
      Montreal Canada
    • Related Report
      2012 Final Research Report
  • [Presentation] 加振動装置固定の適否がMR Elastography に与える影響2011

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行, 高本孝一, 片桐秀樹, 西条寿夫,八木一夫, 本間一弘
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      小倉
    • Related Report
      2012 Final Research Report
  • [Presentation] 拡散強調スパイラルシーケンスの開発と性能評価2011

    • Author(s)
      沼野智一, 兵藤行志, 新田尚隆, 本間一弘
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      小倉
    • Related Report
      2012 Final Research Report
  • [Presentation] MR Elastography を用いた筋収縮による硬度変化の計測2011

    • Author(s)
      畑純一, 沼野智一, 水原和行, 鷲尾利克, 高本孝一, 片桐秀樹, 西条寿夫,本間一弘, 八木一夫, 矢野敬一
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      小倉
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体臓器を対象とした外部加振法の提案2011

    • Author(s)
      鷲尾利克, 水原和行, 沼野智一, 本間一弘
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      小倉
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代型MRI 対応加振動装置の開発と性能評価2011

    • Author(s)
      沼野智一, 川畑義彦
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代型MRI 対応加振動装置によるMR Elastography2011

    • Author(s)
      沼野智一, 川畑義彦, 鷲尾利克, 水原和行, 新田尚隆, 本間一弘
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 簡易的MR Elastography パルスシーケンスによる弾性率画像表示2011

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行, 高本孝一, 八木一夫, 西条寿夫
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Three-Dimensional Diffusion Weighted Imaging of the Acute Cerebral Ischemia Rat Using 3D MP-RAGE MRI2011

    • Author(s)
      T.Numano, A.Marushima, K.Hyodo, K.Homma, K.Suzuki, A.Matsumura
    • Organizer
      2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor X- and Gamma-Ray Detectors Workshop
    • Place of Presentation
      Knoxville USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] MR Elastography撮像用パルスシーケンス2010

    • Author(s)
      沼野智一
    • Organizer
      第38回日本磁気共鳴医学会大会シンポジウム
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Three-Dimensional Diffusion Weighted Imaging of the Acute Cerebral Ischemia Rat Using 3D MP-RAGE MRI2010

    • Author(s)
      T. Numano, A. Marushima, K. Hyodo, K. Homma, K. Suzuki, A. Matsumura
    • Organizer
      2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor X- and Gamma-Ray Detectors Workshop
    • Place of Presentation
      Knoxville USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 新しいMRI対応加振動装置の開発と性能評価2010

    • Author(s)
      沼野智一, 川畑義彦
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] 新しいMRI 対応加振動装置によるMR Elastography2010

    • Author(s)
      沼野智一, 川畑義彦, 鷲尾利克, 水原和行, 新田尚隆, 本間一弘
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] Motion Sensitizing Gradientを用いない高速MREパルスシーケンスによる弾性率画像表示2010

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行, 高本孝一, 新津守, 岩崎信明, 八木一夫, 本間一弘
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] 加振周波数とノイズがElastogramに与える影響2010

    • Author(s)
      畑純一, 沼野智一, 鷲尾利克, 水原和行, 高本孝一, 本間一弘, 八木一夫
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] 外部加振による位相変位量と周期性に関する一考察2010

    • Author(s)
      鷲尾利克, 水原和行, 沼野智一, 本間一弘
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] 超音波周波数帯の振動によるMRE技術の開発2010

    • Author(s)
      本間一弘, 新田尚隆, 小倉卓哉, 白澤江身子, 鷲尾利克, 沼野智一, 水原和行
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] 臨床用MRI装置による簡易的MRエラストグラフィー2010

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行,新津守,八木一夫, 本間一弘
    • Organizer
      第66回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 新しいMRI対応加振動装置の開発と性能評価2010

    • Author(s)
      沼野智一, 川畑義彦
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新しいMRI対応加振動装置によるMR Elastography2010

    • Author(s)
      沼野智一, 川畑義彦, 鷲尾利克, 水原和行, 新田尚隆, 本間一弘
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Motion Sensitizing Gradientを用いない高速MREパルスシーケンスによる弾性率画像表示2010

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行, 高本孝一, 新津守, 岩崎信明, 八木一夫, 本間一弘
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加振周波数とノイズがElastogramに与える影響2010

    • Author(s)
      畑純一, 沼野智一, 鷲尾利克, 水原和行, 高本孝一, 本間一弘, 八木一夫
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 超音波周波数帯の振動によるMRE技術の開発2010

    • Author(s)
      本間一弘, 新田尚隆, 小倉卓哉, 白澤江身子, 鷲尾利克, 沼野智一, 水原和行
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 外部加振による位相変位量と周期性に関する一考察2010

    • Author(s)
      鷲尾利克, 水原和行, 沼野智一, 本間一弘
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床用MRI装置による簡易的MRエラストグラフィー2010

    • Author(s)
      沼野智一, 畑純一, 鷲尾利克, 水原和行, 新津守, 八木一夫, 本間一弘
    • Organizer
      第66回日本放射線技術学会総会学術大会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] METHOD FOR PRODUCTING A MAGNETIC RESONANCE ELASTOGRAM (MRE), DEVICE FOR PRODUCING THE SAME, AND BALL VIBRATOR FOR PRODUCING THE SAME2011

    • Inventor(s)
      Tomokazu NUMANO, Yoshihiko KAWABATA
    • Industrial Property Rights Holder
      Tokyo Metropolitan University
    • Filing Date
      2011-06-14
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] METHOD FOR PRODUCTING A MAGNETIC RESONANCE ELASTOGRAM (MRE), DEVICE FOR PRODUCING THE SAME, AND BALL VIBRATOR FOR PRODUCING THE SAME2011

    • Inventor(s)
      Tomokazu NUMANO, Yoshihiko KAWABATA
    • Industrial Property Rights Holder
      Tokyo Metropolitan University
    • Filing Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 磁気共鳴エラストグラム(MRE)作成方法及び作成装置,並びに磁気共鳴エラストグラム(MRE)作成用のボールバイブレータ2010

    • Inventor(s)
      沼野智一, 川畑義彦
    • Industrial Property Rights Holder
      首都大学東京
    • Filing Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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