Liver regeneration by means of partial splenic embolization(PSE)-associated with autologous bone marrow cell transplantation-

• Project/Area Number: 22791215
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Osaka City University
• Principal Investigator: YAMAMOTO Akira 大阪市立大学, 大学院・医学研究科, 講師 (60419695)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 再生医学 / 放射線

Research Abstract

In this study, we were able to make a rabbit model with chronic liver damage. We confirmed significant fibrosis of the liver. We obtained adequate bone marrow stem cells of rabbit and purified bone marrow contains mesenchymal stem cells. We inserted catheter and infused normal saline to the rabbit in the control group, embolized splenic artery, infused stem cells, and embolized splenic artery and infused bone marrow cells. We confirmed the improvement of the serum bilirubin in the bone marrow plus PSE group ; however many rabbits died. This was considered to be over stress to the rabbit with chronic liver damage model.