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Functional Imaging for Image-Guided Radiotherapy and Adaptive Radiotherapy

Research Project

Project/Area Number 22791216
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionNara Medical University

Principal Investigator

ASAKAWA Isao  奈良県立医科大学, 医学部, 助教 (20382319)

Co-Investigator(Renkei-kenkyūsha) HASEGAWA Masatoshi  奈良県立医科大学, 医学部, 教授 (50251111)
KAJITANI Chikae  奈良県立医科大学, 医学部附属病院, 医員
UTO Fumiaki  大阪物療大学, 保険医療学部, 教授
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords核医学 / 画像誘導放射線治療 / 機能画像 / FDG-PET / 放射線治療計画 / SUV / 増殖分画 / 放射線治療学
Research Abstract

A basic phantom study of target delineation of the gross tumor volume (GTV) containing inhomogeneously distributed18F-fluorodeoxyglucose (FDG) was performed. The contours of the tumor model spheres delineated by using standardized uptake value (SUV) were often different from the actual contours of the spheres. When an insidelayer of the sphere contained no FDG, the SUV of the outer layer was lower than the calculated value.In the clinical study, the data for 53 patients with histologically proven primary squamous cell carcinoma (SqCC) of the head and neck treated with radiotherapy were analyzed. All patients underwent contrast-enhanced (CE)-CT and FDG-PET before radiation therapy planning (RTP). The PET-based GTV (PET-GTV) for RTP was defined using both CE-CTimages and FDG-PET images. The CE-CT-based GTV (CT-GTV) for RTP was defined using CE-CT images alone. Sensitivity of PET-GTV for identifying the primary tumor was 96%, but that of CT-GTV was 81% (p

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (8 results)

  • [Journal Article] Efficacy of FDG-PET for defining gross tumor volume of head and neck cancer2013

    • Author(s)
      Kajitani C, Asakawa I, Uto F, Katayama E, Inoue K, Tamamoto T, Shirone N, Okamoto H, Kirita T, Hasegawa M
    • Journal Title

      J Radiat Res

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of FDG-PET for Defining Gross Tumor Volume of Head and Neck Cancer2013

    • Author(s)
      梶谷千香枝
    • Journal Title

      Journal of Radiation Research

      Volume: Epub ahead of print Issue: 4 Pages: 1-8

    • DOI

      10.1093/jrr/rrs131

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線治療計画における PET/CT の有用性について2012

    • Author(s)
      長谷川正俊、片山絵美子、梶谷千香枝、井上和也、浅川勇雄、玉本哲郎、宇都文昭、吉村均
    • Journal Title

      臨床放射線

      Volume: 57巻 Pages: 49-495

    • Related Report
      2012 Final Research Report
  • [Journal Article] Changes of tumor size and tumor contrastenhancement during radiotherapy for non-small-cell lung cancer may besuggestive of treatment response2012

    • Author(s)
      Okada H, Hontsu S, Miura S, Asakawa I, Tamamoto T, Katayama E, Iwasaki S,Kimura H, Kichikawa K, Hasegawa M
    • Journal Title

      J Radiat Res

      Volume: 53(2) Pages: 326-332

    • NAID

      130001876843

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線治療計画におけるPET/CTの有用性について2012

    • Author(s)
      長谷川正俊、浅川勇雄, 他
    • Journal Title

      臨床放射線

      Volume: 57 Pages: 490-495

    • Related Report
      2011 Annual Research Report
  • [Presentation] 悪性リンパ腫の放射線治療後の経過における FDG-PET 偽陽性の検討2012

    • Author(s)
      片山絵美子、浅川勇雄、他
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 悪性リンパ腫の放射線治療後の経過におけるFDG-PET偽陽性の検討2012

    • Author(s)
      片山絵美子
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] FDG-PET/CT を用いた放射線治療計画の基礎的研究2011

    • Author(s)
      宇都文昭、浅川勇雄、長谷川正俊、他
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2011-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] FDG-PET/CTを用いた放射線治療計画の基礎的研究2011

    • Author(s)
      宇都文昭
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘(奈良)
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 辺縁帯 B 細胞リンパ腫の放射線治療例における FDG-PET と増殖分画の検討2011

    • Author(s)
      長谷川正俊、浅川勇雄、他
    • Organizer
      第70回日本医学放射線学会総会
    • Place of Presentation
      Web 開催
    • Related Report
      2012 Final Research Report
  • [Presentation] 辺縁帯B細胞リンパ腫の放射線治療例におけるFDG-PETと増殖分画の検討2011

    • Author(s)
      長谷川正俊、浅川勇雄, 他
    • Organizer
      第70回日本医学放射線学会総会
    • Place of Presentation
      (Web開催)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 辺縁帯 B 細胞リンパ腫の放射線治療における FDG-PET の検討2010

    • Author(s)
      長谷川正俊、浅川勇雄、他
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 辺縁帯B細胞リンパ腫の放射線治療におけるFDG-PETの検討2010

    • Author(s)
      長谷川正俊
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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