| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Hepatocellular carcinoma(HCC) is naturally resistant toradiotherapy and cytotoxic chemotherapy, leaving surgery as the mainstream therapeuticapproach. On the other hand, it is well known that platelets have a thrombotic effect. However, platelets play an important role not only in hemostasis but also in wound healingand tissue regeneration. Platelets have been reported to accumulate in the liver andpromote liver regeneration after an extended hepatectomy, but the mechanism is unclear. The decrease of platelets of splenomegaly accompanying liver cirrhosis obstructs medicaltreatment, and gives up medical treatment in many cases. Radiation irradiation isconsidered as good adaptation, to splenomegaly by malignant tumors, such as a lymphoma, if the decrease of platelets improves by radiation irradiation in an example with a badreaction, etc. to chemotherapy is increasing also with the benign disease. The decreaseof platelets by hypersplenism accompanying liver cirrhosis is intractable, and can serveas the medical treatment method with effective radiotherapy. Here, the aims of this studyat exploring clinical application of the radiotherapy which is not the present insuranceadaptation as a cure for the plastocytopenia by the splenomegaly accompanying livercirrhosis in this research.
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