Hyaluronan-Conjugated nanoparticles as carrier of sodium borocaptate for tumor targeting in boron neutron capture therapy

• Project/Area Number: 22791229
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Hiroshima International University
• Principal Investigator: KASAOKA Satoshi 広島国際大学, 薬学部, 講師 (90338690)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: BNCT / メラノーマ / DDS / ヒアルロン酸 / 経皮

Research Abstract

We have developed a strategy for targeting sodium borocaptate in melanoma boron neutron capture therapy. The boron-retention capacity of boron formulations was very high. All boborocaptate-loaded nanoparticles had no cytotoxic effects. Hyaluronan-Conjugated nanoparticles readily bound to melanoma cells, and were internalized by receptor-mediated endocytosis. Thermal neutron irradiation yielded tumor growth suppression on B16F10 murine melanoma and COLO679 human melanoma with the Hyaluronan-Conjugated nanoparticles.

Research Products

• [Journal Article] Computed tomography imaging of transferrin targeting liposomes encapsulating both boron and iodine contrast agents by convection-enhanced delivery to F98 rat glioma for boron neutron capture therapy (2011)
  • Author(s): Miyata S, Kawabata S, Hiramatsu R, Doi A, Ikeda N, Yamashita T, Kuroiwa T, Kasaoka S, Maruyama K, Miyatake S.
  • Journal Title: Neurosurgery Volume: 68 Issue: 5 Pages: 1380
  • DOI: 10.1227/neu.0b013e31820b52aa
  • Peer Reviewed
• [Presentation] ヒアルロン酸-ホウ素化合物結合体を用いたホウ素中性子捕獲療法の開発 (2012)
  • Author(s): 増田健二, 笠岡敏, 吉川広之, 櫻井良憲, 増永慎一郎, 小野公二
  • Organizer: 日本薬学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-31
• [Presentation] 新規ヒアルロン酸-BSHコンジュゲートを用いたホウ素中性子捕捉療法の開発 (2011)
  • Author(s): 増田健二, 笠岡敏, 吉川広之, 櫻井良憲, 増永慎一郎, 小野公二
  • Organizer: 中性子捕捉療法学会
  • Place of Presentation: 徳島
  • Year and Date: 2011-09-16
• [Presentation] 新規ヒアルロン酸結合型PEGリポソームを用いたがん化学療法及び中性子捕捉療法の開発 (2011)
  • Author(s): 大亀沙希子, 笠岡敏, 中西莉沙, 小森麻央, 吉川広之, 櫻井良憲, 増永慎一郎, 小野公二
  • Organizer: 日本薬学会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-29