| Project/Area Number |
22791233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MUKAI Hidefumi 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (60570885)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経接着分子 / PETイメージング / 64Cu標識 / PET |
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| Research Abstract |
In the case of peripheral nerve disorder and spinal cord injury, extent of nerve damage and regeneration ability are important for decision of treatment strategy and, therefore, development of molecular probes useful for getting these information is urgently required. In this study, I synthesized peptide ligand derivatives against neural cell adhesion molecule(NCAM), or^<64> Cu-labeled PET probes, and performed PET study using NCAM expressing tumor bearing mice. Additively, I successfully synthesized dendron type PET probes for improvement of affinity and biodistribution by the effect of multimerization and increase of molecular weight.
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