Development of a radioprobe for quantifying brain antioxidant

Research Project

Project/Area Number	22791234
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	National Institute of Radiological Sciences
Principal Investigator	KIKUCHI Tatsuya 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (90392224)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	分子イメージング / PET / 放射性医薬品 / 酸化ストレス / グルタチオン
Research Abstract	In this study, we developed radioprobes for quantifying brain glutathione S-transferase(GST), an antioxidant. Several halogenopurine derivatives were evaluated in vitro and in vivo. Among the derivatives, 6-[F^^<18>] fluoro-9-methylpurine and 6-[B^^<76> r] bromo-9-ethylpurine showed favorable properties for quantifying brain GST activity.

Report

(3 results)