Analysis of molecular mechanisms of lung injury by carbon-ion therapy

• Project/Area Number: 22791235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: FUJITA Hidetoshi 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 研究員 (90571802)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 炭素線 / 肺線維症 / MMP-9 / 系統差 / 肺晩期障害 / 肺線維化 / 放射線治療 / 肺照射 / 遺伝子発現 / MMP

Research Abstract

In lung cancer treatment, carbon-ion(C-ion) radiotherapy is considered to be a cure effective in elderly patients or patients with non-operation adaptation. In this study, we investigated the feature of pneumonia and pulmonary fibrosis after C-ion radiotherapy and molecular mechanisms of lung injury by this treatment using in vivo mouse model. We elucidated that high expression of MMP-9 in fibrotic areas might be a turning point to recover from pulmonary fibrosis after irradiation.

Research Products

• [Journal Article] Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation (2012)
  • Author(s): Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T.
  • Journal Title: Int J Radiat Oncol Biol Phy Volume: (In press)
  • Peer Reviewed
• [Journal Article] Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation (2012)
  • Author(s): Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T
  • Journal Title: International Journal of Radiation Oncology biology physics Volume: (In press)
  • Peer Reviewed
• [Journal Article] Attenuated lung fibrosis in interleukin 6 knock-out mice after C-ion irradiation to lung (2011)
  • Author(s): Saito-Fujita T, Iwakawa M, Nakamura E, Nakawatari M, Fujita H, Moritake T, Imai T.
  • Journal Title: J Radiat Res Volume: 52 Pages: 270-277
  • NAID: 10028111041
  • Peer Reviewed
• [Journal Article] Subtypes of cervical adenosquamous carcinomas classified by EpCAM expression related to radiosensitivity (2010)
  • Author(s): Imadome K, Iwakawa M, Nakawatari M, Fujita H, Kato S, Ohno T, Nakamura E, Ohkubo Y, Tamaki T, Kiyohara H, Imai T.
  • Journal Title: Cancer Biol. Ther Volume: 10 Pages: 1019-1026
  • Peer Reviewed
• [Presentation] 炭素イオン線誘発肺線維症における肺組織りモデリング関連タンパク質の系統間発現解析 (2011)
  • Author(s): 藤田英俊
  • Organizer: 日本放射線影響学会
  • Place of Presentation: 兵庫県神戸商工会議所会館
  • Year and Date: 2011-11-19
• [Presentation] 重粒子線治療がもたらす生物学的効果-がん転移抑制と肺晩発障害- (2011)
  • Author(s): 藤田英俊
  • Organizer: 運動器科学研究会
  • Place of Presentation: 高知県土佐ロイヤルホテル
  • Year and Date: 2011-09-02
• [Presentation] Strain-dependent intra-alveolar hemorrhage with the accumulation of CD44 and Mac3 positive cells after carbon-ion irradiation (2011)
  • Author(s): Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T.
  • Organizer: 14th International Congress of Radiation Research
  • Place of Presentation: Warszawa
• [Presentation] 炭素イオン線誘発肺線維症における肺組織リモデリング関連タンパク質の系統間発現解析 (2011)
  • Author(s): 藤田英俊、中渡美也子、中村悦子、森竹浩之、下川卓志、今井高志
  • Organizer: 第54回日本放射線影響学会
  • Place of Presentation: 兵庫
• [Presentation] 重粒子線治療がもたらす生物学的効果-がん転移抑制と肺晩発障害- (2011)
  • Author(s): 藤田英俊
  • Organizer: 第12回運動器科学研究会
  • Place of Presentation: 高知
• [Presentation] Strain-dependent intra-alveolar hemorrhage with the accumulation of CD44 and Mac3 positive cells after carbon-ion irradiation (2011)
  • Author(s): Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T
  • Organizer: 14th International Congress of Radiation Research (ICRR'2011)
  • Place of Presentation: Warsaw, Poland
• [Presentation] Reduction of lung fibrosis aftercarbon-ion irradiation in Interleukin-6 knock-out mice (2010)
  • Author(s): Fujita H, Saito-Fujita T, Iwakawa M, Nakamura E, Nakawatari M, Moritake T and Imai T.
  • Organizer: 第53回日本放射線影響学会
  • Place of Presentation: 京都