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Analysis of molecular mechanisms of lung injury by carbon-ion therapy

Research Project

Project/Area Number 22791235
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

FUJITA Hidetoshi  独立行政法人放射線医学総合研究所, 重粒子医科学センター, 研究員 (90571802)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords炭素線 / 肺線維症 / MMP-9 / 系統差 / 肺晩期障害 / 肺線維化 / 放射線治療 / 肺照射 / 遺伝子発現 / MMP
Research Abstract

In lung cancer treatment, carbon-ion(C-ion) radiotherapy is considered to be a cure effective in elderly patients or patients with non-operation adaptation. In this study, we investigated the feature of pneumonia and pulmonary fibrosis after C-ion radiotherapy and molecular mechanisms of lung injury by this treatment using in vivo mouse model. We elucidated that high expression of MMP-9 in fibrotic areas might be a turning point to recover from pulmonary fibrosis after irradiation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation2012

    • Author(s)
      Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T.
    • Journal Title

      Int J Radiat Oncol Biol Phy

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation2012

    • Author(s)
      Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T
    • Journal Title

      International Journal of Radiation Oncology biology physics

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuated lung fibrosis in interleukin 6 knock-out mice after C-ion irradiation to lung2011

    • Author(s)
      Saito-Fujita T, Iwakawa M, Nakamura E, Nakawatari M, Fujita H, Moritake T, Imai T.
    • Journal Title

      J Radiat Res

      Volume: 52 Pages: 270-277

    • NAID

      10028111041

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subtypes of cervical adenosquamous carcinomas classified by EpCAM expression related to radiosensitivity2010

    • Author(s)
      Imadome K, Iwakawa M, Nakawatari M, Fujita H, Kato S, Ohno T, Nakamura E, Ohkubo Y, Tamaki T, Kiyohara H, Imai T.
    • Journal Title

      Cancer Biol. Ther

      Volume: 10 Pages: 1019-1026

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 炭素イオン線誘発肺線維症における肺組織りモデリング関連タンパク質の系統間発現解析2011

    • Author(s)
      藤田英俊
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      兵庫県神戸商工会議所会館
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重粒子線治療がもたらす生物学的効果-がん転移抑制と肺晩発障害-2011

    • Author(s)
      藤田英俊
    • Organizer
      運動器科学研究会
    • Place of Presentation
      高知県土佐ロイヤルホテル
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Strain-dependent intra-alveolar hemorrhage with the accumulation of CD44 and Mac3 positive cells after carbon-ion irradiation2011

    • Author(s)
      Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T.
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa
    • Related Report
      2011 Final Research Report
  • [Presentation] 炭素イオン線誘発肺線維症における肺組織リモデリング関連タンパク質の系統間発現解析2011

    • Author(s)
      藤田英俊、中渡美也子、中村悦子、森竹浩之、下川卓志、今井高志
    • Organizer
      第54回日本放射線影響学会
    • Place of Presentation
      兵庫
    • Related Report
      2011 Final Research Report
  • [Presentation] 重粒子線治療がもたらす生物学的効果-がん転移抑制と肺晩発障害-2011

    • Author(s)
      藤田英俊
    • Organizer
      第12回運動器科学研究会
    • Place of Presentation
      高知
    • Related Report
      2011 Final Research Report
  • [Presentation] Strain-dependent intra-alveolar hemorrhage with the accumulation of CD44 and Mac3 positive cells after carbon-ion irradiation2011

    • Author(s)
      Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T
    • Organizer
      14th International Congress of Radiation Research (ICRR'2011)
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reduction of lung fibrosis aftercarbon-ion irradiation in Interleukin-6 knock-out mice2010

    • Author(s)
      Fujita H, Saito-Fujita T, Iwakawa M, Nakamura E, Nakawatari M, Moritake T and Imai T.
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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