Effect of hepatic functional reserve of statin in liver transplantation

• Project/Area Number: 22791248
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: IIDA Taku 京都大学, 医学研究科, 非常勤講師 (90437111)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肝移植 / グラフト機能 / 肝再生 / 免疫抑制作用 / 肝線維化 / 肝繊維化

Research Abstract

This study demonstrated that statin might have the reductive effect of reperfusion injury and liver fibrosis in the early phase after liver transplantation potentially. However statin didn' t have enough effects of immunosuppression after liver transplantation.
There was room in optimal dosage of statin and the modification of rat model.
It must be necessary to continue the evaluation of mechanism of statin in liver transplantation.

Research Products

• [Journal Article] A rare variation of the biliary tree of relevance to live liver donation (2011)
  • Author(s): Iida T, Kaido T, Yoshizawa A, Yagi S, et al
  • Journal Title: Am J Transplant Volume: 11(4) Issue: 4 Pages: 869-70
  • DOI: 10.1111/j.1600-6143.2011.03457.x
  • Peer Reviewed
• [Journal Article] Recurrence of hepatocellular carcinoma after living donor liver transplantation : what is the current optimal approach to prevent recurrence? (2011)
  • Author(s): Kaido T, Mori A, Ogura Y, Hata K, Yoshizawa A, Iida T, Uemoto S
  • Journal Title: World J Surg Volume: 35(6) Pages: 1355-9
  • Peer Reviewed
• [Journal Article] Successful treatment of invasive mucormycosis in a liver transplant patient by arm amputation (2010)
  • Author(s): Iida T, Sawada N, Takahashi M, Zendejas I, Kayler L, Magliocca J, et al
  • Journal Title: Transplant Proc Volume: 42(7) Pages: 2794-6
  • Peer Reviewed
• [Journal Article] Surgery-Related Morbidity in Living Donors for Liver Transplantation (2010)
  • Author(s): Iida T, Ogura Y, Oike F, Hatano E, Kaido T, Egawa H, et al
  • Journal Title: Transplantation Volume: 27, 89(10) Pages: 1276-82
  • Peer Reviewed
• [Journal Article] The rare insertion of b4 with trifurcated portal vein in live donor (2010)
  • Author(s): Iida T, Kaido T, Mori A, Nagata H, Hata K, Koizumi M, et al
  • Journal Title: Transplantation Volume: 89(9) Pages: 116-4
  • Peer Reviewed
• [Journal Article] Successful treatment of pulmonary hypertension secondary to congenital extrahepatic portocaval shunts(Abernethy type 2) by living donor liver transplantation after surgical shunt ligation (2010)
  • Author(s): Iida T, Ogura Y, Doi H, Yagi S, Kanazawa H, Imai H, et al
  • Journal Title: Transpl Int Volume: 23(1) Pages: 105-9
  • Peer Reviewed
• [Journal Article] Uemoto S Posttransplant bacteremia in adult living donor liver transplant recipients (2010)
  • Author(s): Iida T, Kaido T, Yagi S, Yoshizawa A, Hata K, Mizumoto M, Mori A, Ogura Y, Oike F
  • Journal Title: Liver Transpl Volume: 16(12) Issue: 12 Pages: 1379-85
  • DOI: 10.1002/lt.22165
  • Peer Reviewed
• [Journal Article] The rare insertion of b4 with trifurcated portal vein in live donor (2010)
  • Author(s): Iida T, Ogura Y, Oike F, Hatano E, Kaido T, Egawa H, Takada Y, Uemoto S.
  • Journal Title: Transplantation Volume: 27, 89(10) Pages: 1276-82
  • Peer Reviewed
• [Journal Article] Posttransplant bacteremia in adult living donor liver transplantation (2010)
  • Author(s): Taku Iida
  • Journal Title: Liver Transplantation Volume: 12 Pages: 1379-85
  • Peer Reviewed
• [Journal Article] The rare insertion of b4 with trifurcated portal vein in live donor (2010)
  • Author(s): Taku Iida
  • Journal Title: Transplantation Volume: 9 Pages: 1163-64
  • Peer Reviewed
• [Journal Article] Surgery-related morbidity in living donors for liver transplantation. (2010)
  • Author(s): Taku Iida
  • Journal Title: Transplantation Volume: 10 Pages: 1276-82
  • Peer Reviewed
• [Presentation] 血清プロカルシトニン測定による肝移植周術期感染症の評価 (2011)
  • Author(s): 飯田拓
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-04
• [Presentation] 血清プロカルシトニン測定による肝移植周術期感染症の評価 (2011)
  • Author(s): 飯田拓
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2011-10-04
• [Presentation] 術前門脈血栓症を有した成人肝移植症例の長期成績 (2011)
  • Author(s): 飯田拓
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-13
• [Presentation] 術前門脈血栓症を有した成人肝移植症例の長期成績 (2011)
  • Author(s): 飯田拓
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-07-13
• [Presentation] Outcome of adult liver transplant recipients with preoperative portal vein thrombosis (2011)
  • Author(s): Iida T
  • Organizer: The 2011 Joint International Congress of ILTS, ELITA & LICAGE
  • Place of Presentation: Valencia, Spain
  • Year and Date: 2011-06-22
• [Presentation] Outcome of adult liver transplant recipients with preoperative portal vein thrombosis (2011)
  • Author(s): Taku IIDA
  • Organizer: The 2011 Joint International Congress of ILTS, ELITA&LICAGE
  • Place of Presentation: バレンシア(スペイン)
  • Year and Date: 2011-06-22
• [Presentation] 術前ドレナージを要した大量胸腹水合併肝移植レシピエント症例の検討 (2011)
  • Author(s): 飯田拓
  • Organizer: 第23回日本肝胆膵外科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-08
• [Presentation] 術前ドレナージを要した大量胸腹水合併肝移植レシピエント症例の検討 (2011)
  • Author(s): 飯田拓
  • Organizer: 第23回日本肝胆膵外科学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-06-08
• [Presentation] 肝移植周術期における血清プロカルシトニン測定の意義 (2011)
  • Author(s): 飯田拓
  • Organizer: 第111回日本外科学会
  • Place of Presentation: 紙面開催
  • Year and Date: 2011-05-02
• [Presentation] 肝移植周術期における血清プロカルシトニン測定の意義 (2011)
  • Author(s): 飯田拓
  • Organizer: 第111回日本外科学会
  • Place of Presentation: (紙面開催)
  • Year and Date: 2011-05-02