Hybrid transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin-function of islet grafts in diabetic mice

• Project/Area Number: 22791250
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: OHMURA Yoshiaki 大阪大学, 医学部附属病院, 医員 (90571349)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 移植外科学 / 再生医療 / 糖尿病治療 / iPS / ADSC

Research Abstract

Hybrid islet transplantation indicated to promote the survival and insulin function of the islet graft and reduce the islet mass required for reversal of diabetes.

Research Products

• [Journal Article] Combined transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin-function of islet grafts in diabetic mice (2010)
  • Author(s): Yoshiaki Ohmura、Masahiro Tanemura、Naomasa Kawaguchi、Tomohiko Machida、Tsukasa Tanida、Takashi Deguchi、Hiroshi Wada、Shogo Kobayashi、Shigeru Marubashi、Hidetoshi Eguchi、Yutaka Takeda、Nariaki Matsuura、Toshinori Ito、Hiroaki Nagano、Yuichiro Doki、and Masaki Mori
  • Journal Title: Transplantation Volume: 90巻、12号 Pages: 1366-1373
• [Journal Article] Combined transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin-function of islet grafts in diabetic mice. (2010)
  • Author(s): Yoshiaki Ohmura
  • Journal Title: Transplantation Volume: 90(12) Pages: 1366-1373
  • Peer Reviewed
• [Presentation] 脂肪組織由来幹細胞(ADSCs)を応用した次世代型膵島移植法の確立 (2011)
  • Author(s): 大村仁昭
  • Organizer: 第38回日本膵・膵島移植研究会
  • Place of Presentation: 奈良県新公会堂
  • Year and Date: 2011-03-05
• [Presentation] Hybrid islet transplantation with marginal islet mass and adipose tissue-derived stem cells(ADSCs) can elicit long-term islet graft survival and support normoglycemia in diabetic mice (2010)
  • Author(s): 大村仁昭
  • Organizer: 第23回国際移植学会(International Congress of The Transplantation Society)
  • Place of Presentation: バンクーバー・コンベンションセンター、カナダ
  • Year and Date: 2010-08-16
• [Presentation] Hybrid islet transplantation with marginal islet mass and adipose tissue-derived stem cells can elicit long-term islet graft survival and support normoglycemia in diabetic mice. (2010)
  • Author(s): Yoshiaki Ohmura
  • Organizer: XXIII International Congress of The Transplantation Society
  • Place of Presentation: バンクーバー(カナダ)
  • Year and Date: 2010-08-16
• [Patent(Industrial Property Rights)] 膵島移植時の膵島生着率を高める膵島移植の生着改善剤、膵島移植用生物製剤、及び膵島移植用キット (2010)
  • Inventor(s): 種村匡弘
  • Industrial Property Rights Holder: 種村匡弘
  • Filing Date: 2010-08-06
• [Patent(Industrial Property Rights)] 脂肪組織由来幹細胞を用いた膵島移植 (2009)
  • Inventor(s): 種村匡弘、大村仁昭、etc
  • Industrial Property Rights Holder: 大阪大学
  • Filing Date: 2009-12-10
• [Patent(Industrial Property Rights)] マイクロRNAを用いた多能性幹細胞の誘導 (2009)
  • Inventor(s): 森正樹、石井秀始、三吉範克、土岐祐一郎、種村匡弘、永井健一、星野宏光、大村仁昭
  • Industrial Property Rights Holder: 大阪大学
  • Filing Date: 2009-10-14