Molecular mechanism of intercellular adhesion molecule-1 in the development of abdominal aortic aneurysms
| Project/Area Number |
22791252
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
UCHIDA Haruhito 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00550857)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 血管外科学 / 大動脈瘤 / 循環器・高血圧 |
|---|
| Research Abstract |
Angiotensin II was infused into apoE deficient mice(SKO) and ICAM-1xapoE double deficient mice(DKO) to develop abdominal aortic aneurysm(AAA). ICAM-1 deficiency in whole body attenuated the development of AAA. Bone marrow transplantation revealed that ICAM-1 deficiency in the recipient mice reduced the development of AAA. This result suggests that ICAM-1 may play an important role in the development of AAA formation in this model.
|
Report
(3 results)
Research Products
(11 results)
