Molecular mechanism of intercellular adhesion molecule-1 in the development of abdominal aortic aneurysms

• Project/Area Number: 22791252
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Okayama University
• Principal Investigator: UCHIDA Haruhito 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00550857)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 血管外科学 / 大動脈瘤 / 循環器・高血圧

Research Abstract

Angiotensin II was infused into apoE deficient mice(SKO) and ICAM-1xapoE double deficient mice(DKO) to develop abdominal aortic aneurysm(AAA). ICAM-1 deficiency in whole body attenuated the development of AAA. Bone marrow transplantation revealed that ICAM-1 deficiency in the recipient mice reduced the development of AAA. This result suggests that ICAM-1 may play an important role in the development of AAA formation in this model.

Research Products

• [Journal Article] Urokinase-Type Plasminogen Activator Deficiency in Bone Marrow-Derived Cells Augments Rupture of Angiotensin II-Induced Abdominal Aortic Aneurysms (2011)
  • Author(s): Uchida HA, Poduri A, Subramanian V, Cassis LA, Daugherty A
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31(12) Pages: 2845-52
• [Journal Article] Development of Angiotensin II-induced Abdominal Aortic Aneurysms Is Independent of Catalase in Mice (2011)
  • Author(s): Uchida HA, Sugiyama H, Takiue K, Kikumoto Y, Inoue T, Makino H
  • Journal Title: Journal of Cardiovascular Pharmacology Volume: 58(6) Pages: 633-638
• [Journal Article] Urokinase-Type Plasminogen Activator Deficiency in Bone Marrow-Derived Cells Augments Rupture of Angiotensin II-Induced Abdominal Aortic (2011)
  • Author(s): Uchida HA
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Pages: 2845-2852
  • Peer Reviewed
• [Journal Article] Development of Angiotensin II-induced Abdominal Aortic Aneurysms Is Independent of Catalase in Mice (2011)
  • Author(s): Uchida HA
  • Journal Title: Journal of Cardiovascular Pharmacology Volume: 58 Pages: 633-638
  • Peer Reviewed
• [Journal Article] Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice (2010)
  • Author(s): Uchida HA, Kristo F, Rateri LD, Lu H, Carnigo R, Cassis LA, Daugherty A
  • Journal Title: Atherosclerosis Volume: 211(2) Pages: 399-403
• [Presentation] Edaravone Attenuates Angiotensin II-induced Abdominal Aortic Aneurysms in Apolipoprotein E Deficient Mice (2011)
  • Author(s): Uchida HA
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-04-28
• [Presentation] エダラボンは抗酸化作用および抗炎症作用を介して腹部大動脈瘤形成を抑制する (2011)
  • Author(s): 内田治仁
  • Organizer: 第52回日本脈管学会総会
  • Place of Presentation: 長良川国際会議場、岐阜市
• [Presentation] 腹部大動脈瘤形成におけるカラターゼの果たす役割の検討 (2011)
  • Author(s): 内田治仁
  • Organizer: 第52回日本脈管学会総会
  • Place of Presentation: 長良川国際会議場、岐阜市
• [Presentation] Edaravone Attenuates Angiotensin II-induced Abdominal Aortic Aneurysms in Apolipoprotein E Deficient Mice (2011)
  • Author(s): Uchida HA
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology 2011
  • Place of Presentation: Hilton Chicago, Chicago, USA
• [Presentation] アンジオテンシンII負荷腹部大動脈瘤マウスモデルにおけるuPA-uPARカスケードが果たす役割の検討 (2010)
  • Author(s): 内田治仁
  • Organizer: 第51回日本脈管学会総会
  • Place of Presentation: 旭川
• [Presentation] Chronic Infusion of Angiotensin II does not Sensitize Acatalasemic Mice to Development of Abdominal Aortic Aneurysms (2010)
  • Author(s): Uchida HA
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology 2010
  • Place of Presentation: San Francisco, USA