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Induction of tolerance to small intestine allografts by adoptive transfer of in vitro generating regulatory T-cells

Research Project

Project/Area Number 22791262
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionTokyo Medical University

Principal Investigator

ABE Yuta  東京医科大学, 医学部, 助教 (70327526)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords外科 / 免疫学
Research Abstract

We demonstrate the in vitro generation of regulatory T cells(RA-Treg) in the presence of IL-2, TGF beta and all trans retinoic acid(RA) to acquire a gut-homing ability and more potent at suppressing T-cell activation in vitro. We also demonstrate that RA-Treg injected into Naive mice, intestinal ischemia/reperfusion injury mice, syngeneic intestine transplanted mice, allogeneic intestine transplanted mice respectively can reach recipient mesenteric nodes. More increased accumulation of RA-Treg was observed in I/R injury mice, syngeneic transplanted mice, allogeneic transplanted mice than that in naive mice demonstrating the role of I/R injury for accumulation Tregs in this model.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Prediction of a Side Effect and Efficacy of Adjuvant Chemotherapy with Gemcitabine for Post Operative Patient of Pancreatic Cancer by a Genetic Polymorphism Analysis2012

    • Author(s)
      Kasuya K, Tsuchida A, Nagakawa Y, Abe Y, et al
    • Journal Title

      Hepatogastroenterology

      Volume: 59(117) Pages: 1609-13

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Endoscopic placement of a new short-term biodegradable pancreatic and biliary stent in an animal model2011

    • Author(s)
      Itoi T, Kasuya K, Abe Y, Ishiyama H
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 18(3) Pages: 463-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hypoxia-inducible factor-1a expression and gemcitabine chemotherapy for pancreatic cancer2011

    • Author(s)
      Kasuya K, Tsuchida A, Abe Y, et al.
    • Journal Title

      Oncol Rep

      Volume: 26(6) Pages: 1399-406

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hypoxia-inducible factor-1a expression and gemcitabine chemotherapy for pancreatic cancer2011

    • Author(s)
      Kasuya K, Tsuchida A, Abe Y, et al
    • Journal Title

      Oncol Rep

      Volume: 26 Pages: 1399-406

    • DOI

      10.3892/or.2011.1457

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [免疫抑制剤]肝臓と免疫抑制剤2011

    • Author(s)
      阿部雄太, 島津元秀
    • Journal Title

      移植

      Volume: 45-1 Pages: 8-15

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫抑制剤2010

    • Author(s)
      阿部雄太, 島津元秀
    • Journal Title

      肝臓と免疫抑制剤移植

      Volume: 45(1) Pages: 8-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] Endoscopic placement of a new short-term biodegradable pancreatic and biliary stent in a animal model2010

    • Author(s)
      Itoi T, Kasuya K, Abe Y, Ishiyama H
    • Journal Title

      J Hepatobiliary Pancreat Sci

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腎移植患者に対するグラセプターへの切り替えの検討2010

    • Author(s)
      中村有紀, 阿部雄太, 他
    • Organizer
      日本移植学会
    • Place of Presentation
      京都 みやこメッセ
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎移植患者に対するグラセプターへの切り替えの検討2010

    • Author(s)
      中村有紀, 阿部雄太, ほか
    • Organizer
      日本移植学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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