The establishment of a high-pressure gas preservation method, and the elucidation of mechanism.
| Project/Area Number |
22791266
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical University (2012)
National Research Institute for Child Health and Development (2010-2011) |
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Principal Investigator |
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| Research Collaborator |
LI Xiao-kong 国立成育医療研究センター研究所, RI 管理室, 室長 (60321890)
INUBUSHI Masayuki 放射線医学総合研究所, 分子イメージング研究センター, 研究員 (70399830)
NAITO Munekazu 東京医科大学, 医学部, 講師 (10384984)
HIRAI Shuichi 東京医科大学, 医学部, 講師 (70516054)
ITOH Masahiro 東京医科大学, 医学部, 教授 (00232471)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 移植外科学 / 臓器保存 / 移植・再生医療 / 高圧 / 乾燥 |
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| Research Abstract |
We demonstrated that exposure of organs into high-pressure CO and O2-mixed gas without immersion in stock solution leads to the maximum cell-protective effects of gas for preservation. This result is important to show the scientific evidenceand apply for clinical cases. In addition, we succeeded in rat limb preservation for one-week by using high-pressure CO and O2-mixed gas. The result indicates that high-pressure CO and O2-mixed gas is widely useful to organ preservation.
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Report
(4 results)
Research Products
(12 results)
