Investigation of a novel therapeutic target in liver cancer stem cells.

• Project/Area Number: 22791278
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Osaka University
• Principal Investigator: HATANO Hisanori 大阪大学, 医学部附属病院, 医員 (40571352)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肝細胞癌 / 胆管細胞癌 / 癌幹細胞 / 標的治療 / 標的療法

Research Abstract

In our assessment of IHC for CD13 in paraffin sections of HCC, staining patterns were categorized into three, but we couldn' t find out the relationship between the CD13 expression patterns and patients' prognosis.

Research Products

• [Journal Article] Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial-Mesenchymal Transition-like Phenomenon (2011)
  • Author(s): Kim HM, Haraguchi N, Ishii H, Ohkuma M, Okano M, Mimori K, Eguchi H, Yamamoto H, Nagano H, Sekimoto M, Doki Y, Mori M
  • Journal Title: Annals of Surgical Oncology
• [Journal Article] The future prospects and subject of the liver cancer stem cells study for the clinical application (2011)
  • Author(s): Haraguchi N, Ishii H, Nagano H, Doki Y, Mori M
  • Journal Title: Gastroenterology
• [Journal Article] Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial-Mesenchymal Transition-like Phenomenon (2011)
  • Author(s): Kim HM, et.al.
  • Journal Title: Annals of surgical oncology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] The future prospects and subject of the liver cancer stem cells study for the clinical application (2011)
  • Author(s): Haraguchi N, et.al.
  • Journal Title: Gastroenterology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells (2010)
  • Author(s): Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M.
  • Journal Title: J Clin Invest Volume: 120(9) Issue: 9 Pages: 3326-39
  • DOI: 10.1172/jci42550
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells (2010)
  • Author(s): Naotsugu Haraguchi, et.al.
  • Journal Title: The Journal of Clinical Investigation Volume: Volume 120, Number 9 Pages: 3326-3339
  • Peer Reviewed
• [Presentation] 肝細胞癌臨床検体におけるCD13発現の検討- (2011)
  • Author(s): Hisanori Hatano, Shigeru Marubashi, Naotsugu Haraguchi, Hiroshi Wada, Shogo Kobayashi, Hidetoshi Eguchi, Masahiro Tanemura, Hideshi Ishii, Koji Umeshita, Hiroaki Nagano, Yuichiro Doki, Masaki Mori
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-10-04
• [Presentation] Assessment of CD13 expression in clinical hepatocellular carcinoma(HCC)-肝細胞癌臨床検体におけるCD13発現の検討- (2011)
  • Author(s): 畠野尚典, 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] 肝癌の癌幹細胞マーカーの同定と膵癌での検討 (2010)
  • Author(s): Daisuke Takiuchi, Hidetoshi Eguchi, Naotsugu Haraguchi, Hisanori Hatano, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Masahiro Tanemura, Hideshi Ishii, Koji Umeshita, Hiroaki Nagano, Yuichiro Doki, Masaki Mori
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-24
• [Presentation] 肝癌の癌幹細胞マーカーの同定と膵癌での検討 (2010)
  • Author(s): 瀧内大輔, 他
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-24
• [Presentation] 肝癌における癌幹細胞の分離・同定と標的治療の可能性 (2010)
  • Author(s): 畠野尚典, 原口直紹, 石井秀始, 瀧内大輔, 和田浩志, 小林省吾, 丸橋繁, 江口英利, 武田裕, 種村匡弘, 永野浩昭, 土岐祐一郎, 森正樹
  • Organizer: 第31回癌免疫外科研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-05-21
• [Presentation] CD13 is a novel dormant cancer stem cell marker of liver and has a potency as a novel therapeutic target (2010)
  • Author(s): Daisuke Takiuchi, Naotsugu Haraguchi, Hisanori Hatano, Hideshi Ishii, Koji Umeshita, Hiroaki Nagano, Yuichiro Doki, Masaki Mori.
  • Organizer: The 8th Stem Cell Reseach Symposium
  • Place of Presentation: 兵庫県洲本市
  • Year and Date: 2010-05-14
• [Presentation] CD13 is a novel dormant cancer stem cell marker of liver and has a potency as a novel therapeutic target (2010)
  • Author(s): Daisuke Takiuchi, et.al.
  • Organizer: The 8th Stem Cell Research Symposium
  • Place of Presentation: 兵庫県洲本市
  • Year and Date: 2010-05-14
• [Book] 実験医学 (2011)
  • Author(s): 畠野尚典, 原口直紹, 石井秀始, 永野浩昭, 土岐祐一郎, 森正樹
  • Total Pages: 130
  • Publisher: 羊土社
• [Book] 実験医学vol.29No.13(8月号)2011 (2011)
  • Author(s): 畠野尚典, 他
  • Total Pages: 130
  • Publisher: 羊土社
• [Book] Surgery Frontier (2010)
  • Author(s): 畠野尚典, 原口直紹, 石井秀始, 瀧内大輔, 永野浩昭, 土岐祐一郎, 森正樹
  • Total Pages: 100
  • Publisher: メディカルレビュー社
• [Book] Surgery Frontier 2010年6月号 (2010)
  • Author(s): 畠野尚典, 他
  • Total Pages: 100
  • Publisher: メディカルレビュー社