Inflammation inducing resistance for anti-cancer drug
| Project/Area Number |
22791279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胆道癌 / 化学療法抵抗性 / 胆道炎症 / アポトーシス |
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| Research Abstract |
Biliary tract cancer is commonly suffered from inflammation, such as cholangitis, obstructive jaundice, and liver abscess. In this study we evaluated the relationship between this inflammation and chemoresistance. The prognosis of the patients with possibility of cholangitis was poor and the surgical treatment to reduce cholangitis would have benefit for survival. IL-6 and TGF-βamong inflammation cytokines cross-talked in cholangiocarcinoma cells, and induced chemo-resistance for multi-anti cancer drugs. Induced Gemicitabine resistant cholangiocarcinoma cells produced IL-6 and TGF-βand inhibition of smad4 attenuate these chemo-resistance. These indicated that inflammation stimulated IL-6 and TGF-βproduction as cross-talk, which is one of the mechanisms of chemo-resistance for biliary tract cancer.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Hiroaki Nagano Comparison of 4-weekly vs. 3-weekly gemcitabine as adjuvant chemotherapy following curative resection for biliary tract cancer : A prospective randomized controlled trial2011
Author(s)
Shogo Kobayashi, Atsushi Miyamoto, Junzo Shimizu, Masaki Kashiwazaki, Yutaka Takeda, Shigeyuki Ueshima, Yongkook Kim, Toru Kitagawa, Keizo Dono, Masaki Mori, Yuichiro Doki
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Journal Title
Journal of Cancer Therapy
Volume: 2巻
Pages: 703-709
Related Report
Peer Reviewed
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[Presentation] A prospective randomized controlled trial comparing 4-weekly versus 3-weekly adjuvant chemotherapy with gemcitabine after curative resection of biliary tract cancer2012
Author(s)
Shin Nakahira, Shogo Kobayashi, Atsushi Miyamoto, Junzo Shimizu, Masaki Kashiwazaki, Shigeyuki Ueshima, Yongkook Kim, Toru Kitagawa, Keizo Dono, Masaki Mori, Yuichiro Doki and Hiroaki Nagano
Organizer
ASCO-GI
Place of Presentation
USA, Friday
Year and Date
2012-01-20
Related Report
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