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Development of reliable prediction system of early intrahepaticrecurrence of hepatocellular carcinoma after surgery

Research Project

Project/Area Number 22791284
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionYamaguchi University

Principal Investigator

TSUNEDOMI Ryouichi  山口大学, 大学院・医学系研究科, 助教 (10420514)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords癌
Research Abstract

We developed prediction system of the risk of intrahepatic recurrence (IHR) of hepatocellular carcinoma (HCC) after surgery. IHR-related genes were screened by DNA microarray and an amplified fragment length polymorphism-based High Coverage Expression Profiling analyses. Nine genes were identified as IHR-related genes. Those 9 IHR-related genes showed significant differences of prognosis. Our prediction system consists of the combination of mRNA levels showed high performance to prediction of IHR within 2 years after surgery.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (75 results)

All 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (54 results) Patent(Industrial Property Rights) (9 results) (of which Overseas: 4 results)

  • [Journal Article] ABCB6mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma2013

    • Author(s)
      Ryouichi Tsunedomi, 他
    • Journal Title

      International Journal of Oncology

      Volume: 42巻 Pages: 1551-1559

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility of hepatoma-derived cells to histone deacetylase inhibitors is associated with ID2expression2013

    • Author(s)
      Ryouichi Tsunedomi, 他
    • Journal Title

      International Journal of Oncology

      Volume: 42巻 Pages: 1159-1166

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ABCB6 mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma2013

    • Author(s)
      Ryouichi Tsunedomi
    • Journal Title

      International Journal of Oncology

      Volume: 42 Pages: 1551-1559

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility of hepatoma-derived cells to histone deacetylase inhibitors is associated with ID2 expression2013

    • Author(s)
      Ryouichi Tsunedomi
    • Journal Title

      International Journal of Oncology

      Volume: 42 Pages: 1159-1166

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personalized Chemotherapy for Colorectal Cancer based on the genome information2012

    • Author(s)
      Ryouichi Tsunedomi, Shoichi Hazama, and Masaaki Oka
    • Journal Title

      Journal of the Japan Society of Applied Electromagnetics and Mechanics

      Volume: 20巻 Pages: 589-593

    • NAID

      110009544607

    • Related Report
      2012 Final Research Report
  • [Journal Article] Overexpression of the RD RNA binding protein in hepatitis C virus-related hepatocellular carcinoma2012

    • Author(s)
      Michihisa Iida, Ryouichi Tsunedomi, 他
    • Journal Title

      Oncology Reports

      Volume: 28巻 Pages: 728-734

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Personalized Chemotherapy for Colorectal Cancer based on the genome information2012

    • Author(s)
      Ryouichi Tsunedomi
    • Journal Title

      Journal of the Japan Society of Applied Electromagnetics and Mechanics

      Volume: 20 Pages: 589-593

    • NAID

      110009544607

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Overexpression of the RD RNA binding protein in hepatitis C virus-related hepatocellular carcinoma2012

    • Author(s)
      Michihisa Iida
    • Journal Title

      Oncology Reports

      Volume: 28 Pages: 728-734

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers2011

    • Author(s)
      Norio Iizuka, Ryouichi Tsunedomi, 他 24名
    • Journal Title

      Clinica Chimica Acta

      Volume: 412巻 Pages: 152-158

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers2011

    • Author(s)
      Norio Iizuka, Ryouichi Tsunedomi, et al.
    • Journal Title

      Clinica Chimica Acta

      Volume: 412 Pages: 152-158

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylated cyclin D2gene circulating in the blood asa prognosis predictor of hepatocellular carcinoma2010

    • Author(s)
      Masahito Tsutsui, Ryouichi Tsunedomi,他14名
    • Journal Title

      Clinica Chimica Acta

      Volume: 411巻 Pages: 516-520

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma2010

    • Author(s)
      Masahito Tsutsui, Ryouichi Tsunedomi, et al.
    • Journal Title

      Clinica Chimica Acta

      Volume: 411 Pages: 516-520

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肝細胞癌の転移・再発抑制~誘導肝細胞癌幹細胞の解析~2013

    • Author(s)
      恒富 亮一
    • Organizer
      第2回超異分野学会
    • Place of Presentation
      すみだ中小企業センター (東京)
    • Year and Date
      2013-03-16
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 次世代の個別化薬物療法をめざしたイリノテカン毒性予測システムの開発2013

    • Author(s)
      硲 彰一
    • Organizer
      第46回制癌剤適応研究会
    • Place of Presentation
      軽井沢プリンスホテルウエスト (長野)
    • Year and Date
      2013-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] カスタム DNA チップを用いたKRAS 遺伝子変異解析法の開発2012

    • Author(s)
      亀井 修一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡 (福岡)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト膵癌細胞株からの Cancer Stem Cells の誘導2012

    • Author(s)
      吉村 清
    • Organizer
      第25回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      倉敷市芸文館 (岡山)
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] UDP-グルクロン酸転移酵素遺伝子多型の判別による塩酸イリノテカン副作用発現予測法の開発2012

    • Author(s)
      平山 幸一
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      国立京都国際会館 (京都)
    • Year and Date
      2012-11-30
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 肝細胞癌術後肝内再発予測マーカーとしての ABCB6 遺伝子2012

    • Author(s)
      恒富 亮一
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      ルネッサンスリゾートナルト (徳島)
    • Year and Date
      2012-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝細胞癌における MCM6 の発現解析2012

    • Author(s)
      飯田 通久
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      ルネッサンスリゾートナルト (徳島)
    • Year and Date
      2012-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] RELIABLE PREDICTION OF EARLY INTRAHEPATIC RECURRENCE OF HCV-RELATED HEPATOCELLULAR CARCINOMA AFETR SURGERY BY GENE EXPRESSIONAL PROFILING2012

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      20th United European Gastroenterology Week (UEGW2012)
    • Place of Presentation
      RAI 国際会議場 (Amsterdam, THE NETHERLANDS)
    • Year and Date
      2012-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] HCV 関連肝細胞癌における予後予測2012

    • Author(s)
      恒富 亮一
    • Organizer
      第20回日本消化器関連学会週間 (JDDW2012)
    • Place of Presentation
      神戸国際展示場 (神戸)
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト低分化型肝細胞癌株からの癌幹細胞の誘導の試み2012

    • Author(s)
      吉村 清
    • Organizer
      第20回日本消化器関連学会週間 (JDDW2012)
    • Place of Presentation
      ポートピアホテル (神戸)
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Cancer-stem cell-like sphere cells induced from a cell line derived from poorly-differentiated hepatocellular carcinoma2012

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館 (札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Inducing pancreatic cancer stem cell like population by culture and the analysis of its microenvironment2012

    • Author(s)
      Kiyoshi Yoshimura
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館 (札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 培養による膵癌幹細胞 Rich ポピュレーションの誘導時の微小周辺環境の探索2012

    • Author(s)
      吉村 清
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      北海道大学学術交流会館 (札幌)
    • Year and Date
      2012-07-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 血清を用いた CpG island methylator phenotype (CIMP) による予後評価への応用2012

    • Author(s)
      飯田 通久
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ (千葉)
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] カスタムDNAチップを用いたKRAS遺伝子変異解析法の開発2012

    • Author(s)
      亀井 修一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡 (福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト膵癌細胞株からのCancer Stem Cellsの誘導2012

    • Author(s)
      吉村 清
    • Organizer
      第25回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      倉敷市芸文館 (岡山)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝細胞癌術後肝内再発予測マーカーとしてのABCB6遺伝子2012

    • Author(s)
      恒富 亮一
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      ルネッサンスリゾートナルト (徳島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝細胞癌におけるMCM6の発現解析2012

    • Author(s)
      飯田 通久
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      ルネッサンスリゾートナルト (徳島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] RELIABLE PREDICTION OF EARLY INTRAHEPATIC RECURRENCE OF HCV-RELATED HEPATOCELLULAR CARCINOMA AFETR SURGERY BY GENE EXPRESSIONAL PROFILING2012

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      20th United European Gastroenterology Week
    • Place of Presentation
      RAI国際会議場, Amsterdam, THE NETHERLANDS
    • Related Report
      2012 Annual Research Report
  • [Presentation] HCV関連肝細胞癌における予後予測2012

    • Author(s)
      恒富 亮一
    • Organizer
      第20回日本消化器関連学会週間
    • Place of Presentation
      神戸国際展示場 (神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト低分化型肝細胞癌株からの癌幹細胞の誘導の試み2012

    • Author(s)
      吉村 清
    • Organizer
      第20回日本消化器関連学会週間
    • Place of Presentation
      ポートピアホテル (神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血清を用いたCpG island methylator phenotype (CIMP) による予後評価への応用2012

    • Author(s)
      飯田 通久
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ (千葉)
    • Related Report
      2012 Annual Research Report
  • [Presentation] UGT1As 多型の組合せによるイリノテカン副作用予測2011

    • Author(s)
      恒富 亮一
    • Organizer
      第22回日本消化器癌発生学会総会
    • Place of Presentation
      ホテルニューオータニ佐賀 (佐賀)
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] UGT1As多型の組合せによるイリノテカン副作用予測2011

    • Author(s)
      恒富亮一、硲彰一、岡正朗
    • Organizer
      第22回日本消化器癌発生学会総会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] HCV 関連肝細胞癌における Alu repeat メチル化率による予後予測2011

    • Author(s)
      恒富 亮一
    • Organizer
      第19回日本消化器関連学会週間 (JDDW2011)
    • Place of Presentation
      福岡サンパレス (福岡)
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Enhancement of an immune sensitivity of cancer cells by chemotherapeutic agents2011

    • Author(s)
      Shin Kan
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] HCV関連肝細胞癌におけるAlu repeatメチル化率による予後予測2011

    • Author(s)
      恒富亮一、飯塚徳男、岡正朗
    • Organizer
      第19回日本消化器関連学会週間(TDDW2011)
    • Place of Presentation
      福岡サンパレス(福岡)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prediction of intrahepatic recurrence by global and gene-specific DNA methylation markes in non-tumorous liver2011

    • Author(s)
      Ryouichi Tsunedomi, Norio Iizuka, Masahito Tsutsui, Michihisa Iida, Kazuhiko Sakamoto, Takao Tamesa, Masaaki Oka
    • Organizer
      8th International Symposium on Minimal Residual Cancer
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA methylation levels at upstream of ABCB6 correlate with intrahepatic recurrence within 2 years in HCV-related HCC2011

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Year and Date
      2011-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Serum CpG island methylator phenotype (sCIMP) and prognosis of hepatocellular carcinoma2011

    • Author(s)
      Norio Iizuka
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA methylation levels at upstream of ABCB6 correlate with intrahepatic recurrence within 2 years in HCV-related HCC2011

    • Author(s)
      Ryouichi Tsunedomi, Norio Iizuka, Masaaki Oka
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prediction of intrahepatic recurrence by global and gene-specific DNA methylation markes in non-tumorous liver2011

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      8th International Symposium on Minimal Residual Cancer (ISMRC)
    • Place of Presentation
      大阪国際会議場 (大阪)
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] ABCB6 遺伝子をマーカーとしたHCV 関連肝細胞癌の予後予測2011

    • Author(s)
      恒富 亮一
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Year and Date
      2011-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ABCB6遺伝子をマーカーとしたHCV関連肝細胞癌の予後予測2011

    • Author(s)
      恒富亮一、飯塚徳男、飯田通久、筒井理仁、坂本和彦、為佐卓夫、岡正朗
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝細胞癌における ID2 発現レベルとヒストン脱アセチル化酵素阻害剤感受性2011

    • Author(s)
      恒富 亮一
    • Organizer
      第44回制癌剤適応研究会
    • Place of Presentation
      ホテル日航熊本 (熊本)
    • Year and Date
      2011-03-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝細胞癌におけるID2発現レベルとヒストン脱アセチル化酵素阻害剤感受性2011

    • Author(s)
      恒富亮一
    • Organizer
      第44回制癌剤適応研究会
    • Place of Presentation
      熊本・ホテル日航熊本
    • Year and Date
      2011-03-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] ABCB6 遺伝子に基づく HCV 関連肝細胞癌の予後予測2011

    • Author(s)
      恒富 亮一
    • Organizer
      第115回山口医学会学術講演会
    • Place of Presentation
      山口大学霜仁会館 (山口)
    • Year and Date
      2011-02-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 術前血中メチル化 cyclin D2 (CCND2) 遺伝子による肝切除後の早期肝内再発予測2011

    • Author(s)
      筒井 理仁
    • Organizer
      第115回山口医学会学術講演会
    • Place of Presentation
      山口大学霜仁会館 (山口)
    • Year and Date
      2011-02-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ABCB6遺伝子に基づくHCV関連肝細胞癌の予後予測2011

    • Author(s)
      恒富亮一
    • Organizer
      第115回山口医学会学術講演会
    • Place of Presentation
      山口・山口大学霜仁会館
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞癌における RDBP の発現とその機能2011

    • Author(s)
      飯田 通久
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      紙上開催
    • Related Report
      2012 Final Research Report
  • [Presentation] 術前血中メチル化 (SPINT2) 遺伝子による肝切除後の早期肝内再発・全生存期間予測2011

    • Author(s)
      筒井 理仁
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      紙上開催
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝細胞癌におけるRDBPの発現とその機能2011

    • Author(s)
      飯田通久、飯塚徳男、筒井理仁、恒富亮一、前田祥成、坂本和彦、為佐卓夫、岡正朗
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      (震災により紙上開催)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 術前血中メチル化(SPINT2)遺伝子による肝切除後の早期肝内再発・全生存期間予測2011

    • Author(s)
      筒井理仁、飯塚徳男、恒富亮一、飯田通久、坂本和彦、為佐卓夫、岡正朗
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      (震災により紙上開催)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Methylation levels of ABCB6 gene might serve as a useful predictive biomarker for early intrahepatic recurrence of hepatocellular carcinoma2010

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Methylation levels of ABCB6 gene might serve as a useful predictive biomarker for eazly intrahepatic recurrence of hepatocellular carcinoma2010

    • Author(s)
      Ryouichi Tsunedomi, et al.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸・神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ABCB6 TRANSCRIPT AND METHYLATION LEVELS MIGHT SERVE AS USEFUL PREDICTIVE BIOMARKERS FOR EARLY INTRAHEPATIC RECURRENCE OF HEPATOCELLULAR CARCINOMA2010

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      18th United European Gastroenterology Week (UEGW2010)
    • Place of Presentation
      Centre Conventions International Barcelona (Barcelona, SPAIN)
    • Year and Date
      2010-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] ABCB6 TRANSCRIPT AND METHYLATION LEVELS MIGHT SERVE AS USEFUL PREDICTIVE BIOMARKERS FOR EARLY INTRAHEPATIC RECURRENCE OF HEPATOCELLULAR CARCINOMA2010

    • Author(s)
      Ryouichi Tsunedomi, et al.
    • Organizer
      18th United European Gastroenterology Week (UEGW)
    • Place of Presentation
      Barcelona, SPAIN
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Integlins on the surface of tumor cells after sites of metastases2010

    • Author(s)
      Kiyoshi Yoshimura
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場 (大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] ABCB6 mRNA levels in HCV-related hepatocellular carcinoma correlate with development of early intrahepatic recurrence2010

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場 (大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] ABCB6 mRNA levels in HCV-related hepatocellular carcinoma correlate with development of early intrahepatic recurrence2010

    • Author(s)
      Ryouichi Tsunedomi, et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪・大阪国際会議場
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞癌におけるID2発現のHDAC阻害剤への影響2010

    • Author(s)
      恒富亮一
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京・東京ステーションコンファレンス サピアタワー
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞癌における ID2 発現のHDAC 阻害剤への影響2010

    • Author(s)
      恒富 亮一
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京ステーションコンファレンス サピアタワー (東京)
    • Year and Date
      2010-06-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 術前血中メチル化 cyclin D2 (CCND2) 遺伝子による肝切除後の早期肝内再発予測2010

    • Author(s)
      筒井 理仁
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Year and Date
      2010-04-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 術前血中メチル化cyclin D2(CCND2)遺伝子による肝切除後の早期肝内再発予測2010

    • Author(s)
      筒井理仁
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋・国際会議場
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] K-ras における変異検出用オリゴヌクレオチドプローブ2012

    • Inventor(s)
      岡 正朗、硲 彰一、恒富 亮一、平山 幸一、細谷 真悠子
    • Industrial Property Rights Holder
      山口大学、東洋鋼鈑株式会社
    • Industrial Property Number
      2012-259949
    • Filing Date
      2012-11-28
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法2012

    • Inventor(s)
      吉村 清、恒富 亮一、渡邊 裕策、岡 正朗
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Number
      2012-047433
    • Filing Date
      2012-03-02
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] K-rasにおける変異検出用オリゴヌクレオチドプローブ2012

    • Inventor(s)
      岡 正朗、硲 彰一、恒富 亮一
    • Industrial Property Rights Holder
      山口大学、東洋鋼鈑株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-259949
    • Filing Date
      2012-11-28
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法2012

    • Inventor(s)
      吉村清、恒富亮一、渡邊裕策、岡正朗
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Number
      2012-047433
    • Filing Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット2011

    • Inventor(s)
      岡 正朗、硲 彰一、恒富 亮一、浜本 義彦、藤田 悠介、平山 幸一、伊藤 茜
    • Industrial Property Rights Holder
      山口大学、東洋鋼鈑株式会社
    • Filing Date
      2011-05-23
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 肝細胞癌の再発予測マーカー2011

    • Inventor(s)
      恒富 亮一、岡 正朗、飯塚 徳男
    • Industrial Property Rights Holder
      山口大学
    • Filing Date
      2011-03-30
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット2011

    • Inventor(s)
      岡正朗、硲彰一、恒富亮一、浜本義彦、藤田悠介
    • Industrial Property Rights Holder
      山口大学
    • Filing Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 肝細胞癌の再発予測用マーカー2011

    • Inventor(s)
      恒富亮一、岡正朗、飯塚徳男
    • Industrial Property Rights Holder
      山口大学
    • Filing Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット2010

    • Inventor(s)
      岡正朗、硲彰一、浜本義彦、藤田悠介、恒富亮一
    • Industrial Property Rights Holder
      山口大学、東洋鋼鈑(株)
    • Industrial Property Number
      2010-125720
    • Filing Date
      2010-06-01
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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