Development of new efficient cancer-specific artificial viral transduction system

Research Project

Project/Area Number	22791289
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Kyushu University
Principal Investigator	MANABE Tatsuya 九州大学, 医学研究院, 助教 (60546464)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	膵癌 / 人工ウイルス
Research Abstract	Through the study of endocytosis pathway in pancreatic cancer, we found that adenovirus transgene expression has been declining which had been higher expression level of integrinβ3 thanβ5. In addition, we can encapsulate gemcitabine and siRNA of integrinβ3 to the protein nanocapsule Mj285(artificial virus) derived from the small heat shock protein produced by originally developed archaea Methanococcusjannaschii. Furthermore we can bind the virus to the antibody MUC1 by amide bond bioconjugation.

Report

(3 results)